摘要
目的 观察外科手术治疗后肺腺鳞癌（adenosquamous carcinoma,ASC）患者的生存期,探讨肿瘤的病理特征对其预后的影响.方法 回顾性分析2000年1月至2012年6月59例ASC患者的临床资料.选择肿瘤亚型、生物学行为、病理分期等因素,应用SPSS17.0分析影响患者预后的因素.结果 59例ASC患者中位生存时间409天（13.6个月）,1、3、5年生存率分别为59.9％、36.4％及31.2％.59例患者中52例病理标本行基因检测,11例EGFR突变阳性,阳性率为21.2％ （11/52）,2例患者KRAS突变阳性,阳性率3.8％（2/52）.Log-rank检验及Cox多因素分析,病理亚型、胸膜侵及情况、肿瘤分期及辅助放化疗与预后相关,为影响患者预后的独立影响因素（P＜0.05）.结论 肺腺鳞癌患者预后差、生存率低,分析患者病理特征,对高危人群给予综合治疗是使其获得长期生存的关键.
Objective To explore the pathological features affecting the prognosis by observing lung adenosquamous carcinoma overall survival after surgical treatment.Methods Totally 59 cases of lung ASC from 2531 surgically treated lung cancer patients in the First Hospital of Jilin University,from January 2000 to June 2012,were retrospectively analyzed to study their clinical characteristics,survival condition and the related factors influencing the prognosis.Using log-rank test and Cox multiple factors analysis for statistical analysis.Results （1） The 59 patients with ASC were mostly the male patients （62.7%）.The median age was 57.2 years.Median survival time was 409 days（13.6 months）.1-,3-,5-year survival rates were 59.9 %,36.4% and 31.2 %.（2） Among the 59 patients （52 cases of pathological specimens）,11 cases were EGFR mutation positive,positive rate was 21.2%,2 cases of patients were KRAS mutations positive,positive rate was 3.8% ;（3） Single factor and multiple factors analysis showed that the pathological subtype,adjuvant treatment,pleural invasion and tumor stage were associated with prognosis as independent factors （P 〈 0.05）.Conclusion Compared with the simplex lung squamous carcinoma and lung adenocarcinoma,lung adenosquamous carcinoma has poorer prognosis.Early diagnosis and given comprehensive treatment were the keys to prolong its survival.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2014年第11期641-644,共4页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
肺肿瘤
癌
腺鳞状
胸外科手术
肿瘤分期
肿瘤侵润
预后
Lung neoplasms
Carcinoma,adenosquamous
Thoracic surgical procedures
Neoplasm staging
Neoplasm invasiveness
Prognosis
