摘要
目的:探讨c-myc基因检测对宫颈上皮内瘤样病变Ⅰ级(CINⅠ)自然转归的预测价值。方法:对病理组织学初次诊断为CINⅠ的患者43例进行不干预定期随访,采用荧光原位杂交技术检测c-myc基因以了解基线情况,随访6、12、18、24个月时分别行阴道镜病理组织学诊断。结果:43例患者失访3人,失访率6.98%,寿命表法得出平均随访41.3人,随访24个月后自然消退31例(75.1%),病变持续7例(16.9%),进展2例(4.8%)。c-myc阳性组与阴性组在随访12、18、24个月时,自然消退率、持续存在/进展率相比差异均有统计学意义(P<0.05)。结论:CINⅠ在2年内大多数能够自然消退,c-myc基因表达阳性者更易于病变持续和进展,可作为病变进展的辅助监测指标。
Objective： To investigate the predictive value of c-myc gene detection on natural history of the cervical intraepithelial neoplasia grade Ⅰ（ CIN Ⅰ）. Methods： 43 patients with CIN Ⅰ first diagnosed with pathological examination were regularly followed up by without intervention. The baseline data were known by the cmyc genetic testing with fluorescence in situ hybridization. 43 cases were examined repeatedly on the 6th,12 th,18th and 24 th month by colposcopy and histopathology examination. Results： Lost of 3 people in 43 cases,lost of follow up rate was 6. 98%. Life table method was used to calculate the average follow-up of 41. 3 people,after twenty-four months follow up,31 cases（ 75. 1%） were in natural regression,lesions were sustained in 7 cases（ 16. 9%）,and2 cases were in progress（ 4. 8%）. At follow-up 12,18,24 months,the natural regression rate,persistent / progress rate all had statistical significances between c-myc positive group and negative group（ P 〈 0. 05）. Conclusion：Most of CINⅠ can regress themselves during 2 years,sustained lesions and lesions progress are easier for c-myc gene abnormal amplification,so c-myc gene can be used as the monitoring indicators in natural history.
出处
《现代医学》
2016年第10期1426-1429,共4页
Modern Medical Journal
基金
沧州市科学技术局计划资助项目(141302003)
