摘要
目的:探讨高危型人乳头瘤病毒(HR-HPV)感染对轻度宫颈上皮内瘤变(CINⅠ)转归的影响,寻求CINⅠ合理的临床治疗方法。方法:选取2010年1月—12月在天津市滨海新区大港社区医院妇产科门诊经病理学诊断为CINⅠ的妇女,并按照HR-HPV检测结果和患者个人意愿,分为单纯随访组和物理治疗组,并定期随访薄层液基细胞学(TCT)和HR-HPV。结果:经过6,12,24个月随访发现,HR-HPV(-)组无疾病进展病例;HR-HPV(+)组累计进展4例,物理治疗组中进展1例。HR-HPV(-)组与HR-HPV(+)组比较,2组疾病转归差异有统计学意义(P<0.01);物理治疗组疾病进展率低于HR-HPV(+)组,差异有统计学意义(P<0.01);持续HR-HPV感染导致CINⅠ进展的可能性高。结论:持续性HR-HPV感染是CINⅠ进展的高危因素,应合理选择治疗方式,CINⅠ治疗应提倡规范化、个体化和人性化。
Objective：To investigate the impact of high-risk human papillomavirus（HR-HPV）infection fate of mild cervical intraepithelial neoplasia（CIN Ⅰ）,and seek reasonable clinical treatment for CIN Ⅰ.Methods：Select the outpatient women who were diagnozed by pathology for CIN Ⅰ in the Dagang Community Hospital of Tianjin Binhai New Area from January to December in 2010,and divided these women into simple follow-up group and the physical therapy group in accordance with HR-HPV test results and patient wishes of the individual,regular follow-up of TCT and HRHPV.Results：After 6,12,and 24-month follow-up,HR-HPV（-）group had no cases of disease progression;HRHPV（＋） group has four cases in cumulative progression;progress physical therapy group has one case of disease progression.Compared HR-HPV（-）group with the HR-HPV（＋）group,the difference in disease prognosis between the two groups was statistically significan（t P0.01）;compared HR-HPV（＋）group with the physical therapy group,the rate of disease progression in physiotherapy group was less than HR-HPV（＋）group,the difference was statistically significant（P0.01）.The persistent HR-HPV infection led to the likelihood of progression of CIN Ⅰ.Conclusions：Persistent HRHPV infection is the risk factors for CIN Ⅰ progression,which should chose a reasonable treatment,the treatment for CIN Ⅰ should be promoted standardizeuy,individualizelly,and humanistically.
出处
《国际妇产科学杂志》
CAS
2013年第4期324-326,共3页
Journal of International Obstetrics and Gynecology
