摘要
目的对硫酸头孢噻利E型异构体的合成工艺进行研究。方法以氨噻肟酸为起始原料,定向合成硫酸头孢噻利E型异构体。结果合成了目标化合物硫酸头孢噻利E型异构体,并利用1H-NMR、MS确证了结构。精制收率为16.0%,HPLC面积归一化法测得质量分数为94%。结论制备了硫酸头孢噻利E型异构体,为硫酸头孢噻利中杂质研究提供参考。
Objective To study the synthetic technology of E-isomer of cefoselis sulfate. Methods Aminothiaoximo acid was used as the starting material to synthesize E-isomer of cefoselis sulfate. Results The target compound was synthesized and characterized by 1H-NMR and MS. The purified yield of this synthetic route was 16.0%, and the purity of E-isomer of cefoselis sulfate was 94%. Conclusion E-isomer of cefoselis sulfate is obtained which provides reference for impurity study of cefoselis sulfate.
出处
《现代药物与临床》
CAS
2016年第11期1689-1691,共3页
Drugs & Clinic
基金
天津市科技支撑计划重点项目(05YFGZGX03100)
