摘要
目的探讨无创正压通气在急性左心衰中的应用效果。方法选取2015年1月~2016年6月于重庆涪陵中心医院住院治疗的72例急性左心衰患者为研究对象,根据治疗方法的不同将其分为研究组和对照组,每组各36例。两组患者均给予吸氧、镇静、强心、利尿、扩张血管等对症治疗,研究组在此治疗的基础上给予无创正压通气。观察两组患者治疗前、治疗后2 h、治疗后24 h的血浆N末端脑钠肽前体（NT-pro BNP）、超敏C反应蛋白（hs-CRP）的含量,以及呼吸频率（RR）、心率（HR）、平均动脉压（MAP）和动脉血氧分压（PaO_2）、动脉血二氧化碳分压（PaCO_2）、动脉血氧饱和度（SaO_2）等血气分析指标。结果治疗后2、24 h,两组患者NT-pro BNP、hs-CRP均较治疗前显著降低,且治疗后24 h低于治疗后2 h,差异均有统计学意义（P〈0.05或P〈0.01）。治疗后2、24 h,研究组NT-pro BNP水平均显著低于对照组,治疗后2 h研究组hs-CRP低于对照组,差异均有统计学意义（均P〈0.05）。治疗后2、24 h,两组患者RR、HR、MAP、PaCO_2均较治疗前明显降低,PaO_2和SaO_2较治疗前明显升高,差异均有统计学意义（均P〈0.05）;治疗后2、24 h,研究组Pa O2均高于对照组,治疗后24 h PaCO_2低于对照组,差异均有统计学意义（均P〈0.05）。研究组总有效率显著高于对照组,差异有统计学意义（P〈0.05）。结论无创正压通气可迅速缓解急性左心衰患者的临床症状,提高治疗效果,值得临床推广应用。
Objective To study the application effect of noninvasive positive pressure ventilation for the acute left heart failure. Methods Seventy-two patients with breast cancer in Chongqing Fuling Central Hospital from January 2015 to June 2016 were selected as the study objects, they were divided into research group and the control group according to the different treatments, with 36 cases in each group. Patients of the two groups were given symptomatic treatment, such as oxygen inhalation, sedative, strong heart, diuresis, dilate blood vessels. The patients of the research group were given the treatment of noninvasive positive pressure ventilation in addition. Precursor plasma N-terminal brain natriuretic peptide（NT-pro BNP）, hypersensitive C-reactive protein（hs-CRP）, respiratory rate（RR）, heart rate（HR）, mean arterial pressure（MAP） and blood gas analysis, such as arterial partial pressure of oxygen（PaO_2）, arterial partial pressure of carbon dioxide（PaCO_2）, arterial oxygen saturation（SaO_2） and so on, in the two groups before treatment and 2, 24 hours after treatment were observed. Results After treatment for 2, 24 hours, the levels of NT-pro BNP and hs-CRP in the two groups were all significantly reduced compared with those before treatment, and those after treatment for 24 hours were lower than those after treatment for 2 hours, the differences were all statistically significant（P〈0.05 or P〈0.01）.After treatment for 2, 24 hours, the levels of NT-pro BNP in the research group were all significantly lower than those of control group, 2 hours after treatment, the level of hs-CRP in the research group was lower than that of control group, the differences were all statistically significant（all P〈0.05）. After treatment for 2, 24 hours, RR, HR, MAP,PaCO_2 in the two groups were significantly lower than those before treatment, PaO_2 and SaO_2 were obviously higher than those before treatment, the differences were all statistically significant（all P〈0.05）; 2, 24 hours afte
出处
《中国医药导报》
CAS
2016年第32期121-124,共4页
China Medical Herald
关键词
急性左心衰
无创正压通气
血气分析
疗效
Acute left heart failure
Noninvasive positive pressure ventilation
Blood gas analysis
Curative effect
