摘要
目的:探讨N-末端脑钠肽前体(NT-proBNP)与急性心肌缺血冠状动脉病变程度的关系。方法:2006年11月至2007年4月于我院住院明确诊断为急性冠脉综合征的患者70例,根据选择性冠脉造影显示冠脉病变支数的不同分为单支病变组、双支病变组和三支病变(包括左主干病变)组以及冠状动脉狭窄程度的不同分为轻度狭窄组、中度狭窄组和闭塞组,比较各组间NT-proBNP的水平。结果:三支病变组NT-proBNP水平明显高于双支病变组(P<0.05);双支病变组NT-proBNP水平又明显高于单支病变组(P<0.05);闭塞组NT-proBNP水平明显高于中度狭窄组(P<0.05);中度狭窄组NT-proBNP水平又明显高于轻度狭窄组(P<0.05)。结论:急性心肌缺血患者血NT-proBNP浓度随着心肌缺血程度的加重、冠脉病变支数的增加、冠脉狭窄程度的加重而升高,提示NT-proBNP浓度可作为预测急性心肌缺血冠状动脉病变程度的指标之一。
Objective:To analyze the relationship between NT-proBNP and the affection degree of coronary artery in acute myocardial ischemia.Methods:70 cases diagnosed as acute coronary syndrome based on typical clinical symptoms,electrocardiogram,cardiac enzymes and coronary angiography from Nov 2006 to Apr 2007 in our hospital. According to the involved number of coronary artery in coronary angiography(CAG),patients were divided into single-vessel(SV) involved group,double-vessel(DV) involved group and triple-vessel(including left main,TV) involved group.According to the narrowness of the most involved artery in CAG,patients are divided into mild stenosis group,moderate stenosis group and occlusive group.NT-proBNP was compared in each group.Results:NT-pro BNP level in TV involved group was higher than in DV involved group(P<0.05),which was higher than in SV group(P<0.05);NT-pro BNP level in occlusive group was higher than in moderate stenosis group(P<0.05),which was higher than in mild stenosis group(P<0.05).Conclusion:NT-proBNP level increases with the severity of clinical myocardial ischemia,the involved number of coronary artery and the degree of coronary artery stenosis.It suggests that NT-proBNP level may be a factor of predicting the affection degree of coronary artery in acute myocardial ischemia.
出处
《岭南急诊医学杂志》
2009年第1期4-5,52,共3页
Lingnan Journal of Emergency Medicine
关键词
N-末端脑钠肽前体
氨基末端B型钠尿肽前体
急性心肌缺血
NT-pro BNP
amino-terminal NT-pro BNP B-type natriuretic peptide precursor
acute myocardial ischemia
