摘要
目的探讨孕激素保守疗法治疗早期子宫内膜癌的临床疗效及预后。方法选取2013年1月至2015年1月间新疆自治区人民医院妇科收治的60例Ⅰ期子宫内膜癌患者。采用随机数字表法分为观察组和对照组（均要求保留生育功能）,每组30例。观察组患者采用孕激素保守治疗,对照组患者采取刮宫手术。随访12-28个月,比较两组患者近期疗效、妊娠成功率及复发情况。结果观察组患者临床有效率为93.3%（28/30）,对照组患者为60.0%（18/30）,两组比较,差异有统计学意义（P〈0.05）。随访发现观察组患者有11例妊娠成功,成功率为36.7%。对照组患者有4例妊娠成功,成功率为13.3%。观察组高于对照组,差异有统计学意义（P〈0.05）。观察组患者随访期间复发2例,复发率为6.7%,对照组患者复发8例,复发率为26.7%,两组比较差异有统计学意义（P〈0.05）。结论采用孕激素保守治疗早期子宫内膜癌年轻患者,安全有效,患者妊娠率高。
Objective To study the efficacy and prognosis of conservative progestin therapy for early stage endometrial cancers. Methods Sixty patients with stage Ⅰendometrial cancer treated at Xinjiang Uygur Autonomous Region People＇s Hospital from January 2013 to January 2015 were selected. Patients were randomly divided into a control group and an observation group（ fertility function was guaranteed in both groups） with 30 patients in each group. The observation group received conservative progestin therapy and the control group was treated with the conventional curettage. The patients were followed-up for 12 ~ 28 months. Short-term effectiveness,pregnancy and recurrence rate were compared between the two groups.Results The effective rate was 93. 3%（ 28 /30） for the observation group which was higher than 60. 0%（ 18 /30） of the control group（ P〈0. 05）. During the follow-up,it was found that pregnancy rate was36. 7%（ 11 cases） for the observation group which was higher than 13. 3%（ 4 cases） of the control group（ P〈0. 05）. During the follow-up,the recurrence rate for the observation group was 6. 7%（ 2 cases）which was lower than 26. 7%（ 8 cases） of the control group（ P〈0. 05）. Conclusion For younger patients with early endometrial cancer,the conservative progestin therapy is safe and efficient and makes for the successful pregnancy.
出处
《中国肿瘤临床与康复》
2016年第11期1343-1345,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
子宫肿瘤
孕激素
刮宫手术
治疗结果
Uterus neoplasms
Progestin
Curettage surgery
Treatment outcome
