摘要
目的探讨金关片对大鼠痛风性关节炎的药效作用。方法采用尿酸钠晶体制备大鼠痛风性关节炎模型,分别测量大鼠足肿胀度,血清中尿酸(UA)和一氧化氮(NO)的水平及大鼠踝关节软组织中炎症因子(IL-1、IL-6、TNF-α)的含量。结果金关片能显著降低痛风性关节炎模型大鼠踝关节的容积(P<0.05、P<0.01),降低血清中UA、NO的水平(P<0.05、P<0.01)以及关节软组织中IL-1、IL-6、TNF-α的水平(P<0.05、P<0.01)。结论金关片对大鼠痛风性关节炎具有防治作用,其抗炎的机制可能与其降低炎症组织中IL-1、IL-6、TNF-α的含量,减轻其炎症损害有关。
Abstract: OBJECTIVE To observe therapeutical effect of Jinguan tablet(JGT) on gouty arthritis(GA) in rats. METHODS Mon- osodium urate crystals were used to establish GA model in rats. Paw swelling,the level of uric acid(UA) and nitric oxide(NO) in the blood were measured, and ankle joint and soft tissue interleukin - 1 ( IL - 1 ), interleukin - 6 ( IL - 6 ), tumor necrosis factor -α ( TNF - α) levels were also measured. RESULTS JGT could significantly decrease the paw swelling ( P 〈 0.05 or P 〈 0.01 ) , reduce UA and NO in the blood( P 〈 0.05 or P 〈 0.01 ). And reduce the levels of IL - 1, IL - 6 and TNF - α in ankle joint and soft tissue ( P 〈 0.05 or P 〈 0.01 ). CONCLUSION JGT has therapeutical effect on GA.
出处
《华西药学杂志》
CAS
CSCD
2016年第6期584-586,共3页
West China Journal of Pharmaceutical Sciences
关键词
金关片
痛风性关节炎
尿酸
一氧化氮
炎症因子
Jinguan tablet
Gouty arthritis
Uric acid
Nitric oxide
Inflammatory factor