摘要
目的观察控释地诺前列酮阴道栓与米索前列醇治疗过期妊娠的临床疗效及安全性。方法 58例过期妊娠患者随机分为对照组与试验组,各29例。对照组给予米索前列醇,每次25μg,置于阴道后穹窿,平卧30 min未出现宫缩者,24 h后重复给药1次,连用2 d,重复不超过3次;试验组给予控释地诺前列酮阴道栓,每次10 mg,置于阴道后穹窿深处,平卧30 min,出现规律有效宫缩或24 h后取出药物,连用2 d,重复不超过3次。比较2组患者用药到临产的时间、总产程、分娩过程中出血量、24 h内临产率、引产成功率、临床疗效及安全性。结果治疗后,试验组与对照组用药到临产的时间分别为(18.45±2.63),(27.64±3.67)h,产程分别为(8.87±1.41),(13.56±1.79)h,分娩过程中出血量分别为(24.98±3.56),(43.28±6.15)mL,24 h内临产率分别为72.41%(21/29例),55.17%(16/29例),引产成功率分别为89.66%(26/29例),75.86%(22/29例),2组差异均有统计学意义(均P<0.05)。试验组与对照组的临床有效率分别为93.10%(27/29例),79.31%(23/29例),差异有统计学意义(P<0.05)。对照组出现强直性宫缩2例,胎儿窘迫2例,新生儿窒息1例,产后出血1例,药物不良反应的发生率为20.69%(6/29例);试验组出现强直性宫缩1例,药物不良反应的发生率为3.44%(1/29例),2组药物不良反应发生率差异有统计学意义(P<0.05)。结论与米索前列醇比较,控释地诺前列酮阴道栓能够更有效地促进过期妊娠患者宫颈成熟,引产疗效及安全性均较高。
Objective To evaluate the chnical efficacy and safety of controlled released dinoprostone vaginal suppository and misoprostol in the treatment of prolonged pregnancy. Methods A total of 58 patients with prolonged pregnancy were randomly divided into the control group and treatment group, 29 cases in each group. The control group was given misoprostol 25 μg, placed in the posterior foruix of vagina, supined 30 min, the patients had no contraction were administered again after 24 h, for 2 d, no more than 3 times. The treatment group was treated with controlled released dinoprostone vaginal suppository, 10 mg a time, placed in the posterior fornix of vagina, supined 30 min, removed the drug after 24 h or effective uterine contraction appeared, for 2 d, no more than 3 times. Medication to onset of labor time, total production process, amount of bleeding during delivery, onset of labor rate within 24 h, success rate of induced labor, clinical efficacy and safety were compared in two groups. Resrdts After treatment, medication to onset of labor time in treatment group and control group were （ 18.45 ± 2. 63 ）, （27.64 ± 3.67 ） h, total production process were （ 8.87 -± 1.41 ）, （ 13.56 ± 1.79 ） h, amount of bleeding during delivery were （24. 98 ±3.56）, （43.28 ±6. 15） mL, onset of labor rate within 24 h were 72.41% （21/29 cases） ,55.17% （ 16/29 cases）, success rate of induced labor were 89.66% （26/29 cases） ,75.86% （22/29 cases）, the difference all had significant difference （ all P 〈 0. 05 ）. Clinical efficiency in treatment group and control group were 93.10% （27/29 cases）, 79. 31% （23/29 cases, P 〈0. 05）. Control group had 2 cases of tetanic contractions, 2 cases of fetal .distress, 1 case of neonatal asphyxia, 1 case of postpartum hemorrhage, incidence of adverse drug reactions was 20. 69% （6/29 cases）. Treatment group had 1 case of ankylosing contractions, incidence of adverse drug reactions was 3.44% （1/29 cases, P 〈 0. 05 ）. Conclusion Compared
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2016年第23期2138-2140,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家医学教育发展中心医学研究课题基金资助项目(2010-37-02-026)
关键词
控释地诺前列酮阴道栓
米索前列醇
过期妊娠
24
h内临产率
引产成功率
controlled released dinoprostone vaginal suppository
misoprostol
prolonged pregnancy
onset of laborrate within 24 h
success rate of induced labor
