摘要
目的比较甘精胰岛素和门冬胰岛素30对2型糖尿病患者糖脂代谢的影响。方法选取2015年3月至2015年9月于泰州市人民医院就诊的2型糖尿病患者88例。依据随机数字表法分为对照组和观察组,各44例。对照组患者给予甘精胰岛素0.2 U/kg睡前1次皮下注射进行治疗,观察组给予0.2 U/kg门冬胰岛素30晚餐前1次皮下注射进行治疗。比较两组患者治疗前后血糖[空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA_(1c))]、血脂[总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)]水平的变化。结果治疗后,两组患者FPG、2 h PBG、HbA_(1c)均显著低于治疗前,差异有统计学意义(P<0.01)。治疗后观察组和对照组患者FPG[(6.53±0.87)mmol/L比(6.73±0.91)mmol/L]、2 h PBG[(8.34±2.11)mmol/L比(8.51±1.32)mmol/L]、HbA_(1c)[(6.52±0.69)mmol/L比(6.71±0.72)mmol/L]比较差异无统计学意义(P>0.05)。治疗后,两组患者TC、TG和LDL-C均显著低于治疗前(P<0.01)。治疗后,观察组和对照组患者在TC[(4.33±0.79)mmol/L比(4.38±0.88)mmol/L]、TG[(1.34±0.37)比(1.38±0.33)mmol/L]、LDL-C[(2.55±0.54)mmol/L比(2.53±0.57)mmol/L]比较差异无统计学意义(P>0.05)。结论甘精胰岛素和门冬胰岛素30均能有效降低2型糖尿病患者血糖以及血脂水平,值得临床推广。
Objective To compare the effects of insulin glargine and insulin aspart 30 on glucose and lipid metabolism in type 2 diabetes patients. Methods Total of 88 patients with type 2 diabetes treated in Tai Zhou People＇s Hospital from Jan. 2015 to Jun. 2015 were included as research objects,and divided into a control group and an observation group according to the random number method,44 cases in each group. The control group was given insulin glargine 0. 2 U / kg via subcutaneous injection before bedtime,and the observation group was given 0. 2 U / kg insulin aspart 30 via subcutaneous injection before dinner. The changes of blood glucose [fasting plasma glucose（ FPG）,2-hour postprandial blood glucoseb（ 2 h PBG） and glycated hemoglobin（ HbA_（1c）） ]and blood lipid [total cholesterol（ TC）,triglyceride（ TG） and low-density lipoprotein cholesterol（ LDL-C） ] levels were compared between the two groups before and after treatment. Results The levels of FPG,2 h PBG and Hb A1 cwere significantly lower than before treatment,the differences were statistically significant（ P〈0. 01）. There was no significant difference in FPG[（ 6. 73 ± 0. 91） mmol / L vs（ 6. 53 ± 0. 87） mmol/L],2 h PBG[（ 8. 51 ± 1. 32） mmol/L vs（ 8. 34 ± 2. 11） mmol/L] and HbA_（1c）[（ 6. 71 ± 0. 72） mmol/L vs（ 6. 52 ± 0. 69） mmol/L] levels between the two groups after treatment（ P〈0. 05）. After treatment,the total TC,TG and LDL-C of the two groups were significantly lower than before treatment（ P〈0. 01）. There was no significant difference in TC[（ 4. 33 ± 0. 79） mmol / L vs（ 4. 38 ± 0. 88）mmol / L],TG[（ 1. 34 ± 0. 37） mmol / L vs（ 1. 38 ± 0. 33） mmol / L] and LDL-C[（ 2. 55 ± 0. 54） mmol / L vs（ 2. 53 ± 0. 57） mmol / L] between the two groups after treatment（ P〈0. 05）. Conclusion Insulin glargine and insulin aspart 30 can effectively reduce the blood glucose lipid levels in type 2 diabetes patients,thus is worthy of the clinical promotion.
出处
《医学综述》
2016年第22期4559-4561,共3页
Medical Recapitulate
