摘要
目的探讨联合应用异甘草酸镁和熊去氧胆酸对化疗药物所致胃肠道肿瘤患者急性肝损伤的预防作用。方法将经病理学确诊并行化疗的80例胃肠道恶性肿瘤患者纳入研究，随机分为异甘草酸镁联合熊去氧胆酸预防组（观察组）和异甘草酸镁预防组（对照组），每组40例。在化疗前1天以及化疗后1周送检丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、总胆红素（TBiL），并对比两组患者的肝毒性反应发生率。结果80例患者中出现肝功能异常17例，其中观察组5例（12．5％），明显少于对照组的12例（30．0％），差异有统计学意义（P〈0．05）；同时观察组中出现I度毒性反应3例（7．5％），明显少于对照组的8例（20．0％），差异有统计学意义（P〈0．05）。两组患者治疗后肝功能各指标（ALT、AST、TBiL、ALP）水平明显低于对照组，差异有统计学意义（P〈0．05）；且观察组化疗前后肝功能生化各指标的差值显著低于对照组，差异有统计学意义（P〈0．05）。结论联合应用异甘草酸镁和熊去氧胆酸可有效地预防胃肠道肿瘤患者的化疗药物性肝损害。
Objective To observe the efficacy of magnesium isoglycyrrhizinate combined with ursodesoxycholic acid in prevention of chemotherapy drug-induced liver injury in patients with gastrointes- tinal tumors. Methods Eighty patients with early stage gastrointesdnal cancer and indications for sys- temic chemotherapy that had been diagnosed with gastrointestinal malignant tumors by pathology were ran- domly divided into observation group （n = 40）and control group （n = 40 ）. The observation group received chemotherapy drugs combined with magnesium isoglycyrrhizinate and ursodesoxycholic acid, and the con- trol group only received chemotherapy drugs combined with magnesium isoglycyrrhizinate. Results There were 5 cases（ 12. 5% ）with liver injury in the observation group, and 12 cases（30% ）in the control group, the difference was statistically significant（P 〈 0. 05 ）. The levels of ALT, AST, TBiL, ALP after treatment in observation group were significant lower than those of control group, the difference was statistically significant （ P 〈 0. 05 ） ; and the difference of liver function between before and after treat- ment in observation group was significant lower than that of control group, the difference was statistically significant （P 〈 0. 05 ）. Conclusions Magnesium isoglycyrrhizinate combined with ursodesoxycholic acid was effective for the prevention of chemotherapy drug-induced liver damage after initial chemotherapy in patients with early stage gastrointestinal cancer.
出处
《中国实用医刊》
2016年第21期39-41,共3页
Chinese Journal of Practical Medicine
关键词
异甘草酸镁
熊去氧胆酸
肝炎
中毒性
肿瘤
药物疗法
Magnesium isoglycyrrhizinate
Ursodesoxycholic acid
Hepatitis, toxic
Neo-plasms
Drug therapy
