摘要
目的研究血管性痴呆(VaD)患者痴呆程度与血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)和D-二聚体相关性,探讨Hcy、hs-CRP和D-二聚体在血管性痴呆中的作用机制。方法实验分为2组,正常对照组和血管性痴呆组,用散射比浊法检测每份样本中C反应蛋白及D-二聚体含量,采用荧光标记免疫检测法检测血清Hcy水平。结果与正常对照组相比,血管性痴呆组Hcy、hs-CRP、D-二聚体浓度显著增高,差异有统计学意义(P<0.05)。直线相关分析结果提示,HsCRP、Hcy与MMSE评分之间呈负相关性。D-二聚体水平与MMSE评分无相关性。结论同型半胱氨酸、高敏C反应蛋白和D-二聚体参与了VaD的发病机制。血管性痴呆严重程度与Hcy和Hs-CRP呈显著相关性。
Objective To study the relationships between levels of serum homocysteine （Hcy） ,high-sensitive C-reactive protein （hs-CRP）, D-Dimer and vascular dementia （VaD）, and to investigate the mechanism of Hcy, hs-CRP and D-dimer in the vascular dementia. Methods Subjects were divided into normal control group and vascular dementia group. CRP and D-Dimer content were detected by scattering turbidimetry,and the serum Hcy level was detected by fluorescence labeling immunoassay. Results Compared with the normal control group, Hcy,hs-CRP and D-Dimer were significantly higher in the vascular dementi- a group,and the differences were statistically significant. Linear correlation analysis showed negative correlations between Hs- CRP,Hcy and MMSE scores. There was no correlation between the level of D-Dimer and the MMSE scores. Conclusion Hcy, hs-CRP and D-Dimer are involved in the pathogenesis of vascular dementia （VAD）and there are significant correlations be tween the severity of vascular dementia and the levels of Hcy and Hs-CRP.
出处
《中国实用神经疾病杂志》
2016年第24期37-39,共3页
Chinese Journal of Practical Nervous Diseases
基金
河南省科技攻关项目资助
编号122102310160
