摘要
目的研究煤焦油沥青对职业接触工人健康状况及代谢的影响。方法选取煤焦油沥青生产使用企业接触煤焦油沥青职工805例为接触组，不接触煤焦油沥青的管理和后勤人员233例为对照组，对现场进行定点采样测定空气中煤焦油沥青浓度，对工人进行体格检查，做调查问卷，收集工人的基本信息；实验室检测工人尿中代谢产物的含量，作为煤焦油沥青的内暴露量。结果接触组皮肤异常检出率为10．61％，接触组第1秒用力呼气量（FEV。肠）明显低于对照组，差异有统计学意义（P〈0．05）。接触组单核细胞数目、单核细胞百分比明显高于对照组，差异有统计学意义（P〈0．05）；接触组尿中1-羟基芘（1-OHP）、1-羟基萘（1-OHN）、2-羟基萘（2-OHN）含量明显高于对照组，差异有统计学意义（P〈0．05）。结论接触煤焦油沥青职工尿中代谢产物含量明显增高，煤焦油沥青可引起接触工人皮肤瘙痒、色素沉着等病变，肺功能降低。
Objective To investigate the effect of occupational exposure to coal tar pitch on workers＇ health and metabolism. Methods 805 workers exposed to coal tar pitch were selected as exposure group from the produce and employ factory. Other people handle administrative and logistical affairs who not exposed to coal tar pitch were selected as control group. Fix-point sample of air were collected to detect the concentration of coal tar pitch. Do physical examination and questionnaire to collect workers＇ basic and healthy information. To detect the metabolic product of urine samples in laboratory. Results Anomaly detection rate of the skin in exposure group is 10.61. The lung function indices （FEV1.0%） in exposure group were significantly lower than control group （P〈 0.05 ）. The monoeyte count and monocyte rate in exposure group were significantly higher than control group （P〈 0.05 ）. The metabolic product content of PAHS in urine samples is significantly higher in exposed group than control group （P〈O.05）. Conclusion The metabolic product content of polycyclic aromatic hydrocarbon is higher in exposed workers. Coal tar pitch damage workers＇ skin and lung function. It can cause pruritus chromatodermatosis and so on.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
2016年第11期827-829,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
煤焦油沥青
职业暴露
多项筛查
Coal tar pitch
Occupational exposure
Multiphasic screening
