摘要
目的探讨二肽蛋白酶Ⅳ(DPP-Ⅳ)在结核性胸腔积液中的水平变化及其临床价值。方法选取胸腔积液患者86例作为研究对象,包括结核性胸腔积液44例和恶性胸腔积液42例,采用酶联免疫吸附试验(ELISA)法检测DPP-Ⅳ浓度。同时,利用受试者工作特征(ROC)曲线分析DPP-Ⅳ对胸腔积液的诊断价值。结果结核性胸腔积液组患者DPP-Ⅳ、CEA水平显著低于恶性胸腔积液组,而ADA水平显著高于恶性胸腔积液患者,两者差异均有统计学意义(P<0.01)。ROC曲线分析,DPP-Ⅳ水平的检测对结核性胸腔积液的诊断有较大价值。结论 DPP-Ⅳ的检测对结核性胸腔积液和恶性胸腔积液的鉴别诊断有一定的辅助临床参考价值。
Objective To investigate the changes and clinical value of dipeptide protease Ⅳ（ DPP- Ⅳ） in tuberculous pleural effusion. Methods 86 cases of patients with pleural effusion were selected as the research object,including 44 cases of tuberculous pleural effusion and 42 cases of malignant pleural effusion. The concentration of DPP- Ⅳ was detected by enzyme linked immunosorbent assay（ ELISA）. At the same time,the receiver operating characteristic（ ROC） curve was used to analyze the diagnostic value of DPP- Ⅳ in pleural effusion. Results The levels of DPP- Ⅳ,CEA in tuberculous pleural effusions group were significantly lower than that of malignant pleural effusions,and the levels of ADA were significantly higher than malignant pleural effusion,with the differences statistically significant（ P 0. 01）. ROC curve analysis and the detection of pleural effusion DPP- Ⅳ had great value to the diagnosis of tuberculous pleural effusion. Conclusion The detection of DPP- Ⅳ in the differential diagnosis of tuberculous pleural effusion and malignant pleural effusion has a certain auxiliary clinical reference value.
出处
《中国卫生检验杂志》
CAS
2016年第21期3141-3142,3146,共3页
Chinese Journal of Health Laboratory Technology
关键词
二肽蛋白酶Ⅳ
胸腔积液
结核
恶性
临床价值
Dipeptide protease Ⅳ
Pleural effusion
Tuberculous
Malignant
Clinical value
