摘要
目的深入研究Ward区做为骨密度随访指标的临床意义。方法采用美国Norland XR-600双能X线骨密度仪,通过测定58例骨质疏松或骨量减少患者6个月内左股骨近端、正位腰椎、全身骨密度,观察股骨颈、Ward区、L2-4、全身骨密度(BMD)及骨矿含量与瘦体重的百分比(%TBMC/FFM)随时间的变化规律及临床特点;通过测定58例患者血钙、血磷、碱性磷酸酶等生化指标,分析其与骨密度的相关性。结果 1所有患者全身BMD降低,%TBMC/FFM低于5%或为正常低值。2服药治疗组6个月后Ward区BMD显著增加,P=0.0028,P<0.05,差异有统计学意义;股骨颈、L2-4、全身BMD、%TBMC/FFM变化量的P值均大于0.05,差异无统计学意义;未服药组所有观测部位BMD变化均无统计学意义(P>0.05)。3所有患者血钙、血磷、碱性磷酸酶(ALP)等生化指标无明显改变(P>0.05)。结论 Ward区对骨密度变化敏感性高,做为骨质疏松患者的临床随访指标,优于其他部位的骨密度测量。
Objective To further study the clinical significance of Ward region as a bone mineral density（ BMD） followup index. Me thods BMD of the femoral neck,Ward region,L2-4,whole body,and the ratio of bone mineral content and lean body mass percentage（ % TBMC / FFM） with time in 58 cases of osteoporosis was determined using dual-energy X-ray absorptiometry（ DXA,Norland XR-600） in 6 months. Serum levels of calcium,phosphorus,and alkaline phosphatase were examined. The correlation between them and BMD was analyzed. Re sults 1） The whole body BMD decreased and % TBMC / FFMwas lower than 5% or lower-normal value in all patients. 2） BMD of Ward region significantly increased（ P = 0. 0028,P〈0. 05）,but BMD of the femoral neck,L2-4,whole body,and % TBMC /FFMwas not significantly changed（ P〉0. 05） in medication group in 6months. BMD of all observed parts was no significantly changed in non-medication group（ P〉0. 05）. 3） Serum calcium,phosphorus,and alkaline phosphatase were not significantly changed in all patients（ P〉0. 05）. Conclusion BMD of Ward region was more sensitive as clinical followup index than that of other parts in patients with osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2016年第11期1399-1403,共5页
Chinese Journal of Osteoporosis
基金
清华大学医院科学研究基金(110200004)
关键词
骨密度
Ward区
X线
Bone mineral density
Ward region
X-ray
