摘要
目的:探讨类风湿关节炎患者使用糖皮质激素治疗后骨密度的变化情况。方法:选择80例类风湿关节炎患者为研究对象,病程均在1年以上。其中使用慢作用抗风湿药治疗的40例为对照组,使用慢作用抗风湿药+糖皮质激素治疗的40例为实验组。用药后采用双能X线骨密度仪测量两组患者的骨密度,对其腰1-4椎及股骨颈、Ward区和大转子的骨矿含量进行测定,并同时测量CRP、ESR、RF等指标。结果:慢作用抗风湿药物对类风湿关节炎患者骨密度无影响,患者治疗前后骨密度无统计学差异(P>0.05);实验组骨矿减少量明显高于对照组,差异具有统计学意义(P<0.01),尤以Ward区明显;长时间应用糖皮质激素比较短时间应用更容易引发骨质疏松,差异具有统计学意义(P<0.01)。结论:采用慢作用抗风湿药物治疗与骨质疏松的发生无明显相关性;服用糖皮质激素+慢作用抗风湿药物会导致骨丢失、骨量减少甚至骨质疏松,且与患者服用激素类药物的时间呈正相关性。
Objective：To investigate changes in patients with rheumatoid arthritis after treatment with corticosteroids BMD. Meth- ods：Collected in our hospital in 2011 and 2013, 80 patients with rheumatoid arthritis, the course was more than 1 year. Where the use of slow-acting antirheumatic drugs in 40 patients （control group）, using a slow-acting antirheumatie drugs - corticosteroids in 40 patients （experimental group）. After treatment by dual energy X-ray absorptiometry to measure quantitatively lumbar vertebra and neck 1-4, Ward area and the greater trochanter bone mineral content, and simultaneously measuring CRP, ESR, RF and other indicators. Results ： Slow-acting antirheumatic drugs on hone mineral density in patients with rheumatoid arthritis had no effect （P〈 0.05）; experimental group was significantly higher bone mass decrease （P〈0.01）, especially in Ward District obvious; prolonged use of corticosteroids compared short application significantly increased the incidence of osteoporosis （P〈0.01）. Conclusion ： Rheu matoid arthritis patients with slow-acting antirheumatic drugs for treatment of osteoporosis occurs with no obvious correlation, tak- ing glucocorticoid drugs ＋ slow-acting anti-occurrence can cause bone loss, bone loss or osteoporosis, and with the patients taking time steroids were positively correlated.
出处
《亚太传统医药》
2014年第6期112-113,共2页
Asia-Pacific Traditional Medicine
关键词
类风湿关节炎
糖皮质激素
骨密度
Rheumatoid Arthritis
Glucocorticoids
Bone Density
