摘要
目的分析艾迪注射液联合GP化疗方案对非小细胞肺癌(NSCLC)患者的影响。方法选取2012年1月—2014年5月渭南市中心医院收治的NSCLC患者68例,随机分为对照组35例与治疗组33例。对照组患者予以GP化疗方案,21 d为1个化疗周期;治疗组患者在对照组基础上加用艾迪注射液,连续治疗2周。比较两组患者临床疗效、毒副作用(恶心呕吐、白细胞计数下降、血小板计数下降、肝功能异常、肾功能异常)发生情况及治疗前后血常规指标(白细胞计数、血小板计数)、肝功能指标(丙氨酸氨基转移酶、天冬氨酸氨基转移酶)、肾功能指标(血肌酐、尿素氮)。结果两组患者临床疗效比较,差异无统计学意义(P>0.05)。治疗组患者恶心呕吐、白细胞计数下降、血小板计数下降、肾功能异常发生率低于对照组(P<0.05);两组患者肝功能异常发生率比较,差异无统计学意义(P>0.05)。治疗前两组患者白细胞计数、血小板计数及丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐、尿素氮水平比较,差异无统计学意义(P>0.5);治疗后治疗组患者白细胞计数、血小板计数高于对照组,丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐、尿素氮水平低于对照组(P<0.05)。结论艾迪注射液联合GP化疗方案可减少NSCLC患者毒副作用。
Objective To analyze the influence of aidi injection combined with GP chemotherapy regimen in treating patients with non - small cell lung cancer. Methods A total of 68 patients with non - small cell lung cancer were selected in the Central Hospital of Weinan from January 2012 to May 2014,and they were randomly divided into control group（n = 35） and treatment group（n = 33）. Patients of control group received GP chemotherapy,21 days as a chemotherapy cycle;patients of treatment group received extra aidi injection for two weeks based on the treatment of control group. Clinical effect,incidence of toxic and side effects（ including nausea and vomiting,decrease of WBC,decrease of PLT,hepatic dysfunction and renal dysfunction）,index of blood routine examination（including WBC and PLT）,hepatic function（including ALT and AST）and renal function（including Scr and BUN） before and after treatment were compared between the two groups. Results No statistically significant differences of clinical effect was found between the two groups（P ﹥ 0. 05）. The incidence of nausea and vomiting,decrease of WBC,decrease of PLT and renal dysfunction of treatment group were statistically significantly lower than those of control group（ P ﹤ 0. 05）,while no statistically significant differences of incidence of hepatic dysfunction was found between the two groups（P ﹥ 0. 05）. No statistically significant differences of WBC,PLT,ALT,AST,Scr or BUN was found between the two groups before treatment（ P ﹥ 0. 05）;after treatment,WBC and PLT of treatment group were statistically significantly higher than those of control group,while ALT,AST,Scr and BUN of treatment group were statistically significantly lower than those of control group（P ﹤ 0. 05）. Conclusion Aidi injection can effectively reduce the incidence of toxic and side effects of patients with non - small cell lung cancer treated by GP chemotherapy regimen.
作者
马亚梅
姜西玲
MA Ya-mei JIANG Xi-ling(Department of Oncology, the Central Hospital of Weinan, Weinan 714000, China)
出处
《实用心脑肺血管病杂志》
2016年第6期89-92,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
癌
非小细胞肺
药物疗法
联合
艾迪注射液
白细胞
肝肾功能
中西医结合
Carcinoma,non - small - cell lung
Drug therapy,combination
Aidi injection
Leukocytes
Hepatic and renal function
Integrated traditional Chinese and Western medicine
