摘要
目的探讨维持性血液透析患者(maintenance hemodialysis patients,MHP)的执行功能现状。方法在Flanker任务条件下,对16例MHP和15例健康个体进行事件相关电位(event-related potential,ERP)分析,自动记录反应按键正误和反应时间,以重复测量的方差分析和简单效应检验比较其正确率、反应时、N200和P300成分上的差异。结果 MHP组在正确率[F(1,29)=0.881,P=0.879]、一致条件下的反应时与对照组无显著差(P=0.176);不一致条件下MHP组的反应时显著长于对照组(P=0.028);MHP组在Flanker效应下的反应时差也显著大于对照组(t=34.514,P<0.001)。MHP组和对照组在一致/不一致条件N200的波峰值[F(1,28)=17.851,P<0.001]、P300的波幅值[F(1,29)=4.348,P=0.046],均存在任务类型和组别效应的交互作用;在一致条件下,MHP组和对照组N200的波峰值(P=0.912)、P300的波幅值(P=0.452)均无显著差异;在不一致条件下,MHP组N200的波峰值(P=0.048)、P300的波幅值(P=0.049)则显著大于对照组。P300潜伏期的组别主效应显著[F(2,56)=17.482,P<0.001]。结论 MHP的基本认知识别能力和简单反应时正常,但执行功能中的抑制控制能力和冲突监测能力均有明显损害。
Objective To investigate the executive function in maintenance hemodialysis （MHD） patients. Method The event-related potential （ERP） of 16 MHD patients （MHD group） and 15 health people （healthy group） under Flanker task were analyzed. The accuracy and reaction time of key-press action were automatically recorded. We performed analysis of variance （ANOVA） and simple effect test for the repeated measures to compare the differences in accuracy, reaction time, and the components of N200 and P300. Result There were no significant differences in accuracy （F [1,29]=0.881,P=0.176） and reaction time in consistency situation between MHD group and healthy group. The reaction time under inconsistency situation was significantly longer in MHD group than in healthy group （P=0.028）. The reaction time difference under Flanker interference was also significantly longer in MHD group than in healthy group （t=-34.514,P〈0.001）. In both MHD and healthy groups under consistent/inconsistent situations, the peak of N200 [F（1,28）=17.851, P〈 0.001） and the amplititude of P300 [F（1, 29）=4.348, P=0.046] had the interaction between task type and group effect. Under consistent situation, the peak of N200 （P=0.912） and amplititude of P300 （P=0.049） had no significant differences between MHD group and healthy group. Under inconsistent situation, however, the peak of N200 （P=0.048） and the amplititude of P300 （P=0.049） were significant higher in MHD group than in healthy group. The group main effect of P300 latency was significant [F（2,56）=17.482, P〈0.001]. Conclu- sion The basic identification and basic reaction time were normal in MHD patients. However, their cognitive inhibition ability and conflict monitoring ability were impaired.
作者
高小玲
石艳
张明昊
廖元江
LIAO Yuan-jiang SHI Yan ZHANG Ming-hao GAO Xiao-ling(Department of Nephrology, Chongqing Ninth People ＇s Hospital, Chongqing 400700, China Center for Laboratory Teaching ＆ Management, Chongqing Medical University, Chongqing 400016, China)
出处
《中国血液净化》
2016年第11期587-590,共4页
Chinese Journal of Blood Purification
基金
重庆市卫计委2015MSXM117号项目
重庆市科委cstc2015shmszx120069号项目
关键词
Flanker任务
执行功能
行为实验
ERP
Flanker task
Executive function
Behavioral experiment
Event-related potential
