摘要
目的探讨非小细胞肺癌组织中p53表达水平与放化疗治疗疗效的关系。方法选取唐山市人民医院2010年8月—2013年7月完成同步放化疗的113例非小细胞肺癌患者,应用免疫组织化学法检测患者病理组织中p53蛋白的表达,并分析p53蛋白表达与放化疗疗效的关系。结果本组患者p53阳性表达率为45.1%(51/113)。p53表达与患者的年龄、性别、病理类型、临床分期等比较差异均无统计学意义(P>0.05)。全组患者CR33例,PR36例,SD37例,PD7例,计算出ORR为61.1%(69/113),DCR为93.8%(106/113);p53阳性者ORR为43.1%(22/51),p53阴性者ORR为75.8%(47/62),二组ORR比较,差异有统计学意义(P<0.05)。本组患者中位生存期为16个月,其中p53阳性表达组患者中位生存期为13个月,平均生存期为18个月,p53阴性表达组患者中位生存期为20个月,平均生存期为30个月,分析显示二组患者OS间差异有统计学意义(P<0.05)。结论非小细胞肺癌患者组织中p53蛋白表达阴性放化疗的敏感性较高且预后好。
Objective To study the expression of p53 in non-small cell lung cancer, andto investigate its relationship with curative effect of chemoradiation. Methods Detected of the expression of p53 was performed by immunohistochemistry in 113 cases of nonsmall cell lung in Tangshan Peoples Hospital since August 2010 to July 2013. The relationship between its expressions with the curative effect of chemoradiation was analyzed. Results p53 showed positive expression, and it was 45. 1% （51/113）. p53 was not significant differents with gender, age, pathological type , clinical staging（P〉0.05）. On the study, CR, PR, SD, pD were 33, 36, 37 and 7 cases respectively, ORR was 61.1% （ 69/113 ）, DCR was 93.8 % （ 106/ 113） ; ORR of positive p53 was 43.1% （22/51） and 75.8%（47/62） for negative p53, it showed a significant difference（P〈0.05）. The median survival was 16 months for all the patients, positive p53 was 13 months（the median survival was 18 months）, while the mean survival of negative p53 was 20 months （the median survival was 30 months）. OS of two groups showed significant difference（P〈0.05）. Conclusion The sensitivity of negative p53 in nonsmall cell lung cancer is higher and the prognosis is better than the positive p53.
出处
《中国煤炭工业医学杂志》
2016年第11期1531-1534,共4页
Chinese Journal of Coal Industry Medicine
基金
2015年度河北省医学科学研究重点课题计划(编号:20150981)
