摘要
【目的】观察加味丹栀逍遥散联合小金丸治疗结节性甲状腺肿的临床疗效。【方法】采用区组随机化法将90例结节性甲状腺肿患者分配到对照1组、对照2组和观察组,每组各30例。对照1组口服加味丹栀逍遥散,对照2组口服小金丸,观察组口服加味丹栀逍遥散和小金丸,以1个月为疗程,共观察3个疗程。观察3组临床疗效及治疗前后甲状腺肿症状评分、甲状腺肿物最大直径的变化情况。【结果】(1)治疗后,观察组总有效率为90.00%,优于对照1组的73.33%和对照2组的66.67%,差异均有统计学意义(P<0.05)。(2)治疗后,3组甲状腺肿症状评分均较治疗前显著改善(P<0.05),甲状腺最大肿物的最大直径均较治疗前显著缩小(P<0.05),且观察组的改善作用均优于对照1组和对照2组,差异均有统计学意义(P<0.05)。(3)治疗过程中,3组均无不良反应发生。【结论】加味丹栀逍遥散联合小金丸治疗结节性甲状腺肿,能明显缩小结节性甲状腺肿及改善甲状腺肿症状。
Objective To observe the clinical effect of modified Dan Zhi Xiaoyao Powder combined with Xiaojin Pills for the treatment of nodular goiter. Methods Ninety patients with nodular goiter were assigned to control group 1, control group 2 and trial group by block random method, 30 cases in each group. Control group 1 was treated with modified Dan Zhi Xiaoyao Powder, control group 2 was given oral use of Xiaojin Pills, and trial group received modified Dan Zhi Xiaoyao Powder combined with Xiaojin Pills orally. One month constituted a treatment course, and the treatment lasted for 3 courses. The therapeutic effect of the three groups was evaluated after treatment, and the scores of goiter symptoms as well as the maximum thyroid neoplasm diameter were observed before and after treatment. Results （1）After treatment, the total effective rate of the trial group was 90.00%, being superior to 73.33% in the control group 1 and 66.67% in the control group 2, and the differences were significant （P 〈 0.05）.（2） The scores of goiter symptoms of the three groups were much improved after treatment compared with those before treatment （P 〈 0.05） , and the thyroid neoplasm maximum diameter was also reduced （P 〈 0.05） . The effect of the trial group on improving goiter symptoms and the maximum thyroid neoplasm diameter was better than that of the two control groups （P 〈 0.05）. （3） During the treatment, no adverse reactions occurred in the three groups. Conclusion Modified Dan Zhi Xiaoyao Powder combined with Xiaojin Pills is effective for the treatment of nodular goiter by obviously reducing nodular goiter size and relieving the goiter symptoms.
出处
《广州中医药大学学报》
CAS
2016年第6期810-812,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
