摘要
目的:探讨支原体肺炎患儿血清Th细胞因子IFN-γ和IL-4水平及临床应用价值。方法:收治肺炎患儿139例(包括支原体肺炎72例)和健康儿童30例,测定血清IFN-γ和IL-4水平,比较组间差异。结果:支原体肺炎患儿血清IFN-γ水平显著高于健康儿童,但低于其他肺炎患儿(P<0.05),IL-4水平显著高于其他肺炎患儿和健康儿童(P<0.05),而支原体肺炎患儿的IFN-γ/IL-4比值均低于其他肺炎患儿和健康儿童(P<0.05)。结论:支原体肺炎患儿急性期Th2细胞介导的免疫较Th1细胞占优,检测IFN-γ和IL-4水平的变化有助于支原体肺炎病情及预后的判断,在儿童支原体肺炎的诊疗中具有十分重要的意义。
ObjectiveTo explore the level of IFN-γ and IL-4 of serum Th cytokine in children with mycoplasma pneumonia andclinical application value.Methods：139 cases of pneumonia（including 72 cases of mycoplasma pneumonia） and 30 cases of healthychildren were selected.The serum levels of IFN-γ and IL-4 were detected.We compared the differences between groups.Results：In children with mycoplasma pneumonia,the level of serum IFN-γ was significantly higher than that of healthy children,but waslower than that of other children with pneumonia（P〈0.05）.IL-4 levels were significantly higher than those of other children withpneumonia and healthy children（P〉0.05）.In children with mycoplasma pneumonia,the ratio of IFN-γ to IL-4 was lower thanthose of other children with pneumonia and healthy children（P〈0.05）.Conclusion：In the acute phase of children with mycoplasmapneumonia,Th2 cell mediated immunity was dominant than Th1 cell.IFN-γ and IL-4 levels detection was helpful to judge thecondition and prognosis of mycoplasma pneumonia.It had very important significance in the diagnosis and treatment ofmycoplasma pneumonia in children.
出处
《中国社区医师》
2016年第33期142-143,共2页
Chinese Community Doctors
关键词
儿童支原体肺炎
TH细胞
Γ干扰素
白介素4
Children with mycoplasma pneumonia
Th cells
γinterferon
Interleukin 4
