摘要
碘是合成甲状腺激素和维持机体正常生理功能的重要元素。碘过量可引起甲状腺功能减退、甲状腺功能亢进、自身免疫性甲状腺疾病等,不同个体对碘过量的易感性不同,过度的氧化应激及继发的免疫反应可能是碘过量引起甲状腺细胞毒性的潜在机制。本文对碘过量的流行病学现状、推荐摄入量和摄入来源、机体对碘过量的调节机制及其相关致病机制做一综述。
Iodine is a key element in the synthesis of thyroid hormones and maintaining the normal physiologicalfunction. The iodine excess can lead to hypothyroidism, hyperthyroidism and autoimmune thyroid diseases. Individuals havedifferent susceptibility to iodine excess. Excessive oxidative stress and secondary immune response may be the potentialmechanisms of thyrotoxicity induced by iodine excess. This review updates the epidemiological results of iodine excess, andrecommended intake standards, which may be involved in iodine excess and the regulatory mechanisms and pathogenesis inbody to counteract iodine excess.
出处
《天津医药》
CAS
2016年第11期1322-1325,共4页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81273009)
天津市科委课题(16JCYBJC26100
09JCYBJC11700)
关键词
碘
甲状腺素
促甲状腺素
碘过量
流行病学
参考值
致病机制
氧化应激
免疫反应
iodine
thyroxine
thyrotropin
iodine excess
epidemiology
reference values
pathogenic mechanism
oxidative stress
immune reaction
