摘要
目的探讨血清炎症因子白细胞介素18(IL-18)、白细胞介素10(IL-10)、肿瘤坏死因子-α(TNF-α)与多囊卵巢综合征(PCOS)发病的关系。方法选取36例PCOS患者为观察组,选取同期月经周期、激素水平及超声检查正常的健康女性志愿者36例为对照组,测定身高、体重、腰围、臀围及血清卵泡刺激素(FSH)、黄体生成激素(LH)、睾酮(T)、空腹血糖(FBG)、胰岛素(INS)、IL-18、IL-10、TNF-α水平。结果观察组患者血清LH、T、INS、Homa-IR、IL-18、TNF-α水平高于对照组,差异有统计学意义(P<0.05),且与体重指数(BMI)、腰臀比(WHR)、INS、Homa-IR显著正相关;IL-10水平低于对照组(P<0.05),且与BMI、WHR、INS、Homa-IR显著负相关。结论慢性炎症可能参与PCOS发病,且与胰岛素抵抗及肥胖有关。
Objective To explore the relationships between serum inflammatory factors-interleukin-18 （IL-18 ）, interleukin-10 （IL-10）, tumor necrosis factor-α （TNF-α） and polycystic ovary syndrome （PCOS） . Methods Thirty-six PCOS patients were selected as observation group; thirty-six healthy women with normal menstrual cycle, hormones levels, and ultrasound findings during the same period were selected as control group. Height, weight, waist circumference, hip circumference, and serum levels of follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, testosterone （T）, fasting blood glucose （FBG）, insulin （INS）, IL-18, IL-10, TNF-α were meas- ured. Results The levels of serum LH, T, INS, HOMA-IR, IL-18, TNF-α in observation group were statistically significantly higher than those in control group （P〈0. 05 ）, which were significantly positively correlated with body mass index （BMI）, waist-to-hip ratio （WHR）, INS, HOMA-IR. The level of serum IL-10 in observation group was statistically significantly lower than that in control group （P〈 0. 05）, which were significantly negatively correlated with BMI, WHR, INS, HOMA-IR. Conclusion Chronic inflammation may participate in pathogenesis of PCOS, which is correlated with insulin resistance and obesity.
出处
《中国妇幼保健》
CAS
2016年第22期4635-4636,共2页
Maternal and Child Health Care of China
基金
吉林省卫生计生委项目(2015Zf ZC13)
吉林省教育厅项目(吉教科合字[2016]第21号)
