摘要
目的:探讨瞬时弹性成像技术脂肪衰减参数(FAI值)在不同中医证型脂肪肝诊断中的应用。方法:选取本院治疗的非酒精性单纯性脂肪肝患者148例和健康对照组144例。使用Fibro Touch检测非酒精性单纯性脂肪肝患者和健康对照组的FAI值,按照2011年制定的《非酒精性脂肪性肝病中西医诊疗共识意见》对非酒精性单纯性脂肪肝患者进行中医辨证分型,并用彩色多普勒超声诊断仪进行脂肪肝超声分级。结果:对非酒精性单纯性脂肪肝患者与健康人的FAI值进行比较,发现患者的FAI值明显高于健康人(t=37.414,P=0.000),表明FAI值可用于定量检测非酒精性单纯性脂肪肝;比较不同分级中医证型非酒精性单纯性脂肪肝患者的FAI值,发现不同中医证型FAI值各不相同(F=3.15,P<0.05),且重度痰瘀互结证患者的FAI值明显高于中度和轻度(P<0.05),中度患者显著高于轻度(P<0.05),表明FAI值可用于诊断脂肪肝的病变程度;对FAI值与非酒精性单纯性脂肪肝分级进行相关性分析,发现FAI值和脂肪肝程度呈正相关(r=0.758,P=0.000),随着脂肪肝程度的加重,FAI值随之升高;采用ROC曲线分析,FAI值诊断轻度脂肪肝ROC曲线下面积为0.807、中度脂肪肝ROC曲线下面积为0.979,表明FAI值对非酒精性单纯性脂肪肝的检测准确率高。结论:瞬时弹性成像技术脂肪衰减参数可定量、准确诊断非酒精性单纯性脂肪肝。
Objective： .To explore the application of fat attenuation parameter with instantaneous elastic imaging- technology （ F AI value） tothe diagnosis of fatty liver of different TCM syndromes. Methods： Totally 148 patients with non-alcoholic and simple fat- ty liver were selected and 114 healthy people were selected as control group. The FAI value in both groups was detected by Fibro- Touch. According to the Consensus on the Chinese and Western Medicine Diagnosis and Treatment for Non-Alcoholic and Simple Fatty Liver established in 2011 ,the patients with non-atcohohe and simple fatty liver were conducted TCM syndrome differentia- tion and performed ultrasonic grading of the fatty liver by color doppler ultrasonic diagnosis apparatus. Results ： The value of FAI in patients with non-alcoholic and simple fatty liver was obviously higher than that in healthy people （T = 37. 414, P = 0. 000） , indicating value of FAI could be used for the quantitative determination of the non-alcoholic and simple fatty liver. The FAI walues vary from different TCM syndromes （F = 3. 15, P 〈 0. 05 ） , and the value of FAI in patients with severe intermingling of phlegm and blood stasis was apparently higher than that in moderate and mild patients （P 〈0.05 ） ; The FAI value in moderate patients was markedly higher than that in mild patients （P 〈 0.05）, indicating that the value of FAI can be used to diagnose the lesion degree of fatty liver. The currelation analysis of the FAI value and the grading of non-alcoholic and simple fatty liver indica- ted that the FAI value is positively related to the degree of fatty liver （r =0. 758,P =0. 000） ; with the increase of the severity of fatty liver, the FAI value increased. With ROC curve analysis, the area under the curve （AUC） of patients with mild fatty liver was 0. 807, that of patients with moderate fatty liver was 0. 979, indicating that FAI value has high accuracy rate in diagnosing non-alcoholic and simple fatty liver. Conclusion： Fat attenuation para
出处
《河南中医》
2016年第11期1940-1942,共3页
Henan Traditional Chinese Medicine
基金
沈阳市自然科学规划基金(编号:15w27)
关键词
非酒精性单纯性脂肪肝
脂肪衰减参数
肝郁气滞证
肝郁脾虚证
痰湿内阻证
湿热蕴结证
痰瘀互结证
non-alcoholic and simple fatty liver
fat attenuation parameter
live depression and qi stagnation syndrome
liver de-pression and spleen deficiency syndrome
internal obstruction of phlegm and dampness syndrome
internal accumulation of damp-heat syndrome
syndrome of intermingling of phlegm and blood stasis
