摘要
目的 观察依托咪酯不同输注速度对胸外科手术患者麻醉诱导期肌阵挛的影响。方法 胸外科手术患者120例,按照依托咪酯输注速度不同分为A组（200μg/s）与B组（400μg/s）各60例。于开始静注依托咪酯即刻（T_0）、注药停止时（T_1）、停止注药后3 min时（T_2）记录两组患者心率（HR）、平均动脉压（MAP）及血氧饱和度（SpO_2）指标;观察记录两组患者麻醉诱导期肌阵挛发生情况。结果 两组患者T0时HR、MAP及SpO_2指标比较均无显著差异（P〉0.05）,HR、Sp O2不同时间点均无明显变化（P〉0.05）,但A组MAPT_1、T_2时间点明显高于B组,差异有显著性（P〈0.05）。A组诱导期肌阵挛发生率（6.7%）明显低于B组（38.3%）,差异有显著性（χ~2=8.235,P〈0.05）。结论麻醉诱导期采用依托咪酯慢速（200μg/s）滴注可有效降低肌阵挛的发生率,且对降低应激反应有益。
Objective To observe the influence of different infusion rates of etomidate on myoclonus in patients receiving thoracic opera- tion during anesthesia induction. Methods 120 patients receiving thoracic operation were selected for this study, and they were divided into two groups according to the infusion rate （group A at 200 μg,/s and group B at 400 μg/s）, each group with 60 cases. The heart rate （HR）, mean ar- terial pressure （MAP） and oxyhemoglobin saturation （ SpO2 ） indicators of two groups at the time of infusing etomidate （ TO ）, stopping infusion （ T1 ） and 3 rain after stopping infusion （ T2 ） were recorded. The oeeurrence of myoclonus during anesthesia induction in these two groups was ob- served and recorded. Results There was no significant difference in HR, MAP and SpO2 at TO between these two groups （ P 〉 0. 05 ）, and there was no evident ehange in HR and SpO2 at different time points （ P 〉 0. 05 ）. But the figures of MAP in group A at T1 and T2 were significantly higher than those of group B, and the difference was significant （ P 〈 0.05 ）. The incidence rate of myoclonus during anesthesia induction in group A （6.7%） was evidently lower than that of group B （ 38.3 % ）, and it had significant difference （ x^2 = 8. 235, P 〈 0.05 ）. Conclusion The application of etomidate at low infusion rate （200 μg/s） during anesthesia induction can effectively reduce the incidence of myoclonus, and it can also reduce the stress response.
出处
《临床和实验医学杂志》
2016年第21期2089-2092,共4页
Journal of Clinical and Experimental Medicine
基金
陕西省卫生厅科学研究基金项目(编号:2012B2)
