摘要
目的了解糖尿病足患者血清基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)表达。方法应用ELISA法测定59例2型糖尿病足病、62例糖尿病无足病患者和66例正常对照血清中MMP-9和TIMP-1含量。结果糖尿病足病组和无足病组MMP-9和TIMP-1含量均高于对照组(P<0.05或0.01),且足病组升高更明显(P<0.01)。糖尿病足病组MMP-9/TIMP-1比值高于无足病组和对照组(P<0.01),但其在无足病组和对照组之间差异无统计学意义(P>0.05)。结论糖尿病足患者血清MMP-9和TIMP-1含量明显升高,且有MMP-9/TIMP-1比值失衡。
Objective To investigate levels of matrix metalloproteinase 9 （MMP-9） and tissue inhibitor of matrix metalloproteinase I（TIMP-1） in diabetic foot （DF） patients. Methods Serum contents of MMP-9 and TIMP-1 in 59 type 2 DF patients, 62 non-diabetic foot （NDF） patients, and 66 healthy controls were detected by ELISA. Results MMP-9 and TIMP-1 levels in DF and NDF groups were higher than those in control group （P〈0.01-0.05）, especially in DF group （P〈0.01）. MMP- 9/TIMP-1 ratio in DF group was superior to that in NDF and control groups （P〈0.01）, but its difference between NDF and control groups was insignificant （P〉0.05）. Conclusion There were the increase of serum MMP-9 and TIMP-1 levels and imbalance of MMP-9/TIMP-1 ratio in DF patients.
作者
陈占玲
李春华
孙庆凯
张秀薇
陈伟坤
CHEN Zhan-ling LI Chun-hua SUN Qing-kai ZHANG Xiu-wei CHEN Wei-kun(Department of Endocrinology, Dongguan People＇s Hospital, Dongguan 523059, Chin)
出处
《广东医学院学报》
2016年第2期121-123,共3页
Journal of Guangdong Medical College
