摘要
目的：比较静脉联合口服水化与常规水化预防慢性肾功能不全患者对比剂肾病的作用。方法选择心内科拟行冠脉介入诊治患者48例，分为短时间水化方案组25例，按3 ml/（ kg·h）速度在冠脉介入诊疗术前1 h至术后4 h进行生理盐水水化，按照1 ml/（kg·h）速度在术前4 h至术后10 h口服水化，常规水化方案组23例，按1 ml/（ kg·h）速度在冠脉介入诊疗术前12 h至术后12 h进行生理盐水水化。检测两组患者术前及术后1d、2d、3d血肌酐、胱抑素C水平，统计两组患者对比剂肾病发生率。结果两组患者在术前及术后1d、2d、3d血肌酐、胱抑素C、对比剂肾病发生率差异无统计学意义（ P〉0.05）。结论短时间静脉联合口服水化方案与常规水化方案预防慢性肾功能不全患者对比剂肾病的效果相当。
Objective To compare the effect of intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy in patients with chronic renal insufficiency. Methods A total of 48 patients who were undergoing percutaneous coronary intervention or diagnosis were randomized divided into the short-time hydration group （ 25 cases ） and the conventional hydration group （23 cases）. Patients in the short-time hydration group received intravenous hydration at 3 ml/（kg·h） from 1 hour before the operation to 4 hours after the operation, and oral hydration at 1 ml/（ kg·h） rate from 4 hours before the operation to 10 hours after the operation. Patients in the conventional hydration group received intravenous hydration at 1 ml/（ kg·h） from 12 hours before the operation to 12 hours after the operation. Levels of Serum creatinine （ Scr） and Cystatin C （ CysC） were measured 1 d, 2 d and 3 d preoperative and postoperative, and the incidence of contrast induced nephropathy between two groups was statistically analyzed.Results There was no significant difference in blood Scr, CysC of 1 d, 2 d and 3 d preoperative and postoperative and incidence of contrast nephropathy between two groups （ P〉0. 05 ） . Conclusions The effect of short time intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy has no difference in patients with chronic renal insufficiency.
出处
《中华现代护理杂志》
2016年第27期3971-3974,共4页
Chinese Journal of Modern Nursing
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z2015141）
关键词
肾机能不全
慢性
静脉水化
口服水化
对比剂肾病
Renal insufficiency,chronic
Intravenous hydration
Oral hydration
Contrast-induced nephropathy
