摘要
目的探讨产前诊断染色体核型危险因素,为评估产前诊断指征综合风险提供准确依据。方法对931例进行产前诊断的临床资料进行分析,得出各指征相对应的异常检出率;并通过logistic回归分析获得高危产前诊断指征。结果染色体核型异常检出率为4.83%。Logistic分析后发现父母染色体结构异常、NT增厚、B超示发育异常、唐氏征临界风险是染色体异常的高危因素。结论产前诊断风险评估能够科学有效地辅助临床遗传咨询工作,从而达到提高人口素质与生命质量的目的。
Objective：To analysis correlation about indications of prenatal diagnosis and the detection rate of abnormal karyotype,provide an accurate basis for assessing integrated risk about the indications of prenatal diagnosis. Methods：Based on the clinical data of 931 cases of prenatal diagnosis and abnormality detection rate,obtain high-risk indications of prenatal diagnosis. Results：Karyotype abnormality detection rate 4.83%. Logistic analysis found parental chromosome structural abnormalities,NT thickening,B ultrasound showed abnormalities,Down′s critical risk could lead to high-risk factors of chromosomal abnormalities.Conclusion：Risk assessment of prenatal diagnosis can effectively assist clinical genetic counseling work,so as to improve the population quality and quality of life.
出处
《中国优生与遗传杂志》
2016年第9期51-52,共2页
Chinese Journal of Birth Health & Heredity
