摘要
目的:探讨雌激素补充联合常规治疗多囊卵巢综合征临床观察。方法:选择2010年1月至2013年10月本院收治的育龄期多囊卵巢综合征患者80例,按照随机数字法分为两组,各40例。对照组使用常规治疗,如药物诱导排卵、心理干预等、生活方式调整等,观察组在对照组基础上联合结合雌激素片治疗。随访2年,比较两组治疗后生殖相关激素水平、治疗不良反应、干预后两组卵巢大小及个数、统计2年内两组妊娠方式及结局。结果:治疗后,观察组E2和PRL水平均基本处于正常,且显著低于对照组(P<0.05),骨密度水平高于对照组(P<0.05),观察组发生潮热、生殖道干涩、闭经及骨质疏松的比例显著低于对照组(P<0.05),观察组卵巢小于对照组(P<0.05),卵泡个数少于对照组(P<0.05),观察组自然妊娠比例高于对照组(P<0.05),未妊娠成功比例低于对照组(P<0.05)。结论:雌激素替代治疗能有效的调节多囊卵巢综合征患者性激素水平,改善患者性生活质量,促使患者妊娠成功。
Objectives： To study the efficacy of estrogen therapy joint conventional therapy for polycystic ovary syndrome（ PCOS）. Methods： 80 PCOS patients at childbearing age in our hospital from January 2010 to October 2013 were selected and randomized into two groups,40 patients in each group. The control group received conventional treatment,such as drugs to induce ovulation,psychological intervention and lifestyle adjustments. On such basis,treatment group jointly received estrogen therapy. All patients were followed up for 2 years,to compare the reproductive- related hormone levels,incidence of adverse reactions,ovarian size and number,delivery mode and pregnancy outcome. Results： After treatment,the E2 and PRL levels were basically normal in the observation group,significantly lower than the control group（ P〈 0. 05）; BMD was higher than control group（ P〈 0. 05）; the incidence of hot flashes,genital dryness,the proportion of amenorrhea and osteoporosis were significantly lower in observation group than the control group（ P〈 0. 05）; the ovarian size and number in observation group was smaller and fewer（ P〈 0. 05）; the proportion of spontaneous pregnancy in observation group was high,and the pregnancy failure rate was lower than the control group（ P〈 0. 05）. Conclusion： Estrogen replacement therapy can effectively regulate hormone levels of PCOS patients,which can improve the quality of sex life of patients and prompts successful pregnancy.
出处
《中国性科学》
2016年第10期112-115,共4页
Chinese Journal of Human Sexuality
基金
陕西省宝鸡市卫生局科研支撑项目(2010-17)
关键词
雌激素
多囊卵巢综合征
性生活质量
妊娠
Estrogen
Polycystic ovary syndrome（PCOS）
Quality of sex life
Pregnancy
