摘要
抗肿瘤药物在肿瘤治疗中起到重要作用,但同时具有一定的潜在心脏毒性。抗肿瘤药物对心脏有多种损害机制及不同临床表现,对患者的生存和预后有着明显影响。心脏毒性可表现为心衰,心肌缺血,心律失常和高血压等。心脏毒性的危险因素包括年龄、放疗史、既往心脏病史以及与其他心脏毒性药物联用等。防治方法包括用药前评估,优化用药方式及定期检测等。
Antitumor drugs play an important role in the tumor treatment, but also have certain cardiotoxic side effects. Antitumor drugs have a variety of damage mechanism on the heart and different clinical manifestations, which have obvious effects on prognosis and survival. Cardiotoxicity can manifest in many ways, such as heart failure, myocardial ischemia, arrhythmia and high blood pressure. Common factors increasing a patient＇s risk of developing cardiotoxicity include age, history of radiotherapy, previous history of heart disease and combination with other cardiotoxic drugs. Prevention and treatment of these toxicities include evaluation before medication, optimal medication method, and regular inspection and so on.
作者
刘倩欣
向倩
李晓颖
赵楠
崔一民
LIU Qian-xin XIANG Qian LI Xiao-ying ZHAO Nan CUI Yi-min(Department of Pharmacy, The First Hospital of Peking University, Beijing 100034, China Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, Beijing 100191, China Department of Radiotherapy, The First Hospital of Peking University, Beijing 100034, China)
出处
《临床药物治疗杂志》
2016年第5期75-78,共4页
Clinical Medication Journal
关键词
肿瘤
抗肿瘤药物
靶向治疗
心脏毒性
tumor
antitumor drugs
targeted therapy
cardiotoxicity
