摘要
目的探讨超声心动图评价乳腺癌患者曲妥珠单抗靶向药物治疗后早期心脏毒性的价值。方法对40例首次接受曲妥珠单抗靶向治疗的乳腺癌患者于治疗前后进行超声心动图检查,包括常规参数、组织多普勒参数及左心房容积指数(LAVI)。结果治疗后Sm、Em、Em/Am降低,Am与E/Em均升高,LAVI治疗后亦升高,且E/Em与LAVI呈正相关(r=0.82,P<0.05)。结论乳腺癌患者接受曲妥珠单抗治疗后,早期心脏毒性主要表现为舒张功能减退。组织多普勒、E/Em、LAVI可作为评价早期左心功能损伤的指标。
Objective To explore the value of echocardiography in evaluation of early cardiotoxicity in breast cancer patients with trastuzumab targeted therapy. Methods A total of 40 breast cancer patients with trastuzumab targeted therapy were conducted with echocardiography examination before and after treatment,including conventional parameters,tissue Doppler imaging parameter and left arterial volume index（ LAVI）. Results After treatment,Sm,Em and Em / Am deceased while Am,E / Em as well as LAVI increased,and there was a positive correlation between E / Em and LAVI（ r = 0. 82,P〈0. 05）. Conclusion The main manifestation of early cardiotoxicity is left ventricular diastolic dysfunction in breast cancer patients with trastuzumab targeted therapy. Tissue Doppler imaging parameter,E / Em and LAVI can be used as indicators for evaluation of early left ventricular dysfunction.
出处
《实用临床医药杂志》
CAS
2016年第11期99-101,共3页
Journal of Clinical Medicine in Practice
关键词
曲妥珠单抗
超声心动图
心脏毒性
左心室舒张功能
trastuzumab
echocardiography
cardiotoxicity
left ventricular diastolic function
