摘要
目的:探讨亚低温联合纳洛酮治疗小儿病毒性脑炎的临床效果及其对于患儿脑脊液中CRP,IL-6及TNF-α的影响。方法:利用随机数字表法将180例病毒性脑炎患儿分为试验组90例(常规治疗+亚低温联合纳洛酮)和对照组90例(仅使用常规治疗)。两组疗程均为14 d,治疗结束后,比较两组临床疗效及不良反应情况。同时在治疗的第0、7、14天分别抽取两组患儿脑脊液,检测两组患儿脑脊液中CRP,IL-6及TNF-α变化情况。结果:试验组和对照组总有效率分别为95.6%和83.3%,其差异具有统计学意义(P<0.05);试验组和对照组不良反应发生率分别为2.3%和3.3%,两组并无统计学差异(P>0.05);相比对照组,试验组患儿脑脊液中CRP,IL-6及TNF-α改善的水平分别均优于对照组,其差异具均有统计学意义(P<0.05)。结论:亚低温联合纳洛酮治疗小儿病毒性脑炎临床疗效确切,并能够降低炎性细胞因子,保护神经元细胞,改善脑部神经功能。
Objective： To observe the therapeutic efficacy and effects of mild hypothermia combined with naloxone on CRP, IL-6 and TNF-α in children with viral encephalitis. Methods： The data of 180 patients with viral encephalitis from January 2014 to January 2015, 90 patients were divided into treatment group and treated by mild hypothermia combined with naloxone, and the other 90 patients were divided into control group and treated by regular methods. The effect of therapy can be evaluated by the references and the contents of CRP, IL-6 and TNF-α were detected in the cerebrospinal fluid by ELISA and Beckman Array 360 System. Results： The total effective rate in treatment group and control group were 95.6% and 83.3%（P〈0.05）. The invalid rates of the groups were 2.3% and 3.3%, and there was no significance between the two groups.The treatment group of mild hypothermia combined with naloxonecan firmly decrease the CRP, IL-6 and TNF-α, and improve the recovery of neurological function on viral encephalitis. Conclusion： The early therapy of mild hypothermia combined with naloxone can improve therapeutic efficacy and obviously decrease the levels of CRP, IL-6 and TNF-α in children with viral encephalitis.
作者
张孝兴
李倩
杨凯龙
韩鹏
ZHANG Xiao-xing LI Qian YANG Kai-long HAN Peng(Intensive care unit Ophthalmology and otorhinolar）,ngology, Children＇s Hospital of Baoji Women ＆ Children Healthcare Hospital, Shanxi Baoji 721000, China)
出处
《临床药物治疗杂志》
2016年第5期41-44,共4页
Clinical Medication Journal
关键词
亚低温
纳洛酮
小儿病毒性脑炎
脑脊液
炎性因子
Mild hypothermia
naloxone
cerebrospinalfluid
children with viral encephalitis
inflammatory factors
