摘要
目的分析及研究Toll样受体及T淋巴细胞亚群与脓毒症的关系,以为脓毒症的诊治提供依据。方法选取2015年1月-2016年4月医院诊治55例脓毒症患者为观察组,另选取同期55名健康体检者为对照组,比较两组研究对象外周血单核细胞Toll样受体(TLR-2、TLR-4、TLR-7及TLR-9)及T淋巴细胞亚群指标,然后比较观察组中不同严重程度脓毒症患者上述血液指标,同时采用logistic分析Toll样受体及T淋巴细胞亚群与脓毒症的关系。结果观察组TLR-2、TLR-4、TLR-7及TLR-9水平分别为(39.89±3.59)%、(17.33±1.60)%、(18.85±1.79)%及(62.68±7.32)%,其均高于对照组(16.16±1.53)%、(8.20±0.71)%、(3.31±0.28)%及(41.51±5.20)%;T淋巴细胞亚群指标均低于对照组,且观察组中脓毒症、严重脓毒症及脓毒性休克患者的检测水平也存在明显差异;经logistic分析,Toll样受体及T淋巴细胞亚群均与脓毒症有密切的关系,差异有统计学意义(P<0.05)。结论脓毒症患者Toll样受体及T淋巴细胞亚群指标呈现明显异常状态,且其严重程度对上述指标的表达影响较大,应重视对上述指标的监测与改善。
OBJECTIVE To observe the correlation between Toll‐like receptors ,T‐lymphocyte subsets and sepsis so as to provide guidance for clinical diagnosis and treatment of sepsis .METHODS Totally 55 patients with sepsis who were treated in the hospital from Jan 2015 to Apr 2016 were chosen as the observation group ,meanwhile ,55 healthy people who received physical examination were set as the control group .The peripheral blood mononuclear cell Toll‐like receptors（TLR‐2 ,TLR‐4 ,TLR‐7 and TLR‐9）and T‐lymphocyte subsets indexes were compared be‐tween the two groups of study objects ,then the blood indexes were observed and compared among the patients with different severities of sepsis ,and the logistic analysis was performed to observe the correlation between Toll‐like receptors ,T‐lymphocyte subsets and sepsis .RESULTS The levels of TLR‐2 ,TLR‐4 ,TLR‐7 ,and TLR‐9 of the observation group were respectively （39 .89 ± 3 .59）% ,（17 .33 ± 1 .60）% ,（18 .85 ± 1 .79）% ,and（62 .68 ± 7 .32）% ,higher than （16 .16 ± 1 .53）% ,（8 .20 ± 0 .71）% ,（3 .31 ± 0 .28）% ,and （41 .51 ± 5 .20）% of the control group .The T‐lymphocyte subsets indexes were lower in the observation group than in the control group;the de‐tection levels varied significantly among the patients with moderate sepsis ,the patients with severe sepsis ,and pa‐tients with septic shock in the observation group .The logistic analysis showed that the Toll‐like receptors and T‐lymphocyte subsets were closely associated with the sepsis ,and there was significant difference （P〈 0 .05） . CONCLUSION The Toll‐like receptors and T‐lymphocyte subsets indexes of the patients with sepsis show signifi‐cant abnormal state ,and the severity of sepsis has great impact on the expression of the above indexes .It is neces‐sary to pay attention to surveillance and improvement of the above indexes .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第22期5090-5092,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81272065)
