摘要
MicroRNAs(miRNAs)是微小非编码RNA,控制基因表达、参与生理病理过程,很多miRNAs主动或被动释放到循环系统中,可用于评价健康状态和疾病进程,是新生物标志物的候选者。miR-375是人和小鼠胰岛中表达量最高的一个miRNA,可作为胰岛特异的标志物,也是糖尿病潜在的新生物标志物。本文对循环miR-375作为T2DM新生物标志物的研究进展和存在问题作简要综述。
MicroRNAs （miRNAs） are small noncoding RNAs,which control gene expression and participate in many physiopathological processes. Hundreds of miRNAs actively or passively released into the circulation can be used to evaluate health status and disease progression, and be potential candidate of new biomarkers, miR-375 is highly expressed in human and rodent islets and used as specific marker of islets and potential new biomarker for diabetes mellitus. This paper reviews the research progress and exiting problems of miR-375 as a new biomarker for type 2 diabetes mellitus.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2016年第11期1029-1031,共3页
Chinese Journal of Diabetes
基金
国家自然科学基金(81471001)
