摘要
目的：探讨前清蛋白（PA）、心肌酶、C 反应蛋白（CRP）检测在重症手足口病（HFMD）合并心肌损伤患儿诊治中的应用价值。方法选取183例手足口病患儿作为观察组，其中重症患儿54例，普通患儿129例，另选取100例同期健康体检儿童作为对照组，检测所有研究对象血清 PA、α-丁酸脱氮酶（α-HBDH），肌酸激酶（CK），肌酸激酶同工酶（CK-MB）、CRP 的水平并进行比较。结果观察组血清 PA 水平为（194．37±42．86）mg／L，对照组为（267．15±52．04）mg／L，观察组血清 PA 水平明显低于对照组（t ＝5．942， P ＜0．05）；观察组血清α-HBDH、CK、CK-MB 及 CRP 分别为（261．58±61．40）U ／L、（124．80±67．51）U ／L、（38．79±16．26）U ／L 和（18．06±5．27）mg／L，对照组血清α-HBDH、CK、CK-MB 及 CRP 分别为（112．93±28．56）U ／L、（103．94±60．86）U ／L、（15．17±9．34）U ／L 和（4．82±0．95）mg／L，观察组α-HBDH、CK、CK-MB及 CRP 均明显高于对照组（t ＝8．356、5．087、9．446、10．755，均 P ＜0．05）。重症组血清 PA 水平为（144．92±40．36）mg／L，普通组为（230．89±46．27）mg／L，重症组血清 PA 水平明显低于普通组（t ＝7．035，P ＜0．05）；重症组血清α-HBDH、CK、CK-MB 及 CRP 分别为（301．58±71．40）U ／L、（145．31±67．84）U ／L、（43．66±18．95）U ／L 和（21．86±6．55）mg／L，普通组血清α-HBDH、CK、CK-MB 及 CRP 分别为（162．93±28．56）U ／L、（116．05±61．37）U ／L、（24．75±12．04）U ／L 和（7．25±3．82）mg／L，重症组患儿血清α-HBDH、CK、CK-MB 及CRP 均明显高于普通组（t ＝9．440、6．204、11．038、13．118，均 P ＜0．05）。重症 HFMD 合并心肌损伤患儿血清PA 水平为（131．02±36．54）mg／L，重症组为（149．73±42．81）mg／L，重症 HFMD 合并心肌损伤组血清 PA 水平明显低于重症组（t
Objective To investigate the clinical significance of prealbumin （PA）,enzymes,C -reactive protein （CRP）detection in severe hand -foot -mouth disease （HFMD）children with myocardial injury.Methods 183 children with HFMD were selected as the observation group,in which 54 children were severe,129 cases were common.100 healthy children during the same period were selected as the control group.PA,α-acid dehydrogenase （α-HBDH）,creatine kinase （CK）,creatine kinase （CK -MB）,CRP levels were detected in the serum of all sub-jects and compared.Results The serum level of PA in the observation group was （194.37 ±42.86）mg/L,which was significantly lower than （267.15 ±52.04）mg/L of the control group （t =5.942,P 〈0.05）.The serum levels ofα-HBDH,CK,CK -MB and CRP in the observation group were （261.58 ±61.40）U /L,（124.80 ±67.51）U /L, （38.79 ±16.26）U /L and （18.06 ±5.27）mg/L,which were significantly higher than those of the control group [（112.93 ±28.56）U /L,（103.94 ±60.86）U /L,（15.17 ±9.34）U /L and （4.82 ±0.95）mg/L,t =8.356,5.087, 9.446 and 10.755,all P 〈0.05].The serum PA level of the severe HFMD group was （144.92 ±40.36）mg/L, which was significantly lower than （230.89 ±46.27）mg/L of the ordinary HFMD group （t =7.035,P 〈0.05）.The＆amp;nbsp;serum levels of α-HBDH,CK,CK -MB and CRP in the severe HFMD group were （301.58 ±71.40）U /L, （145.31 ±67.84）U /L,（43.66 ±18.95）U /L and （21.86 ±6.55）mg/L,which were significantly higher than those in the ordinary HFMD group [（162.93 ±28.56）U /L,（116.05 ±61.37）U /L,（24.75 ±12.04）U /L and （7.25 ± 3.82）mg/L,t =9.440,6.204,11.038 and 13.118,all P 〈0.05].The serum PA level of the severe HFMD with myocardial injury group was （131.02 ±36.54）mg/L,which was significantly lower than （149.73 ±42.81）mg/L of the severe HFMD group （t =7.801,P 〈0.05）.The serum levels of α-HBDH,CK,CK -MB and CRP in the severe HFMD with myocardial injury group were （32
出处
《中国基层医药》
CAS
2016年第22期3500-3503,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
手足口病
心肌损伤
前清蛋白
心肌酶
C
反应蛋白质
Hand -foot -mouth disease
Myocardial injury
Prealbumin
Enzymes
C -Reactive protein
