摘要
目的:探讨天麦消渴片联合盐酸二甲双胍片对糖耐量异常患者胰岛素抵抗、胰岛β细胞及肝脏脂肪含量的影响。方法:120例糖耐量异常患者,随机分为对照组和观察组,各60例。两组患者均给予生活方式干预,饮食控制,并治疗相关基础病如降压、调脂等。两组患者均口服盐酸二甲双胍片。随餐服,每次0.5 g,每日3次。观察组在对照组基础上口服天麦消渴片,1次2片,每日2次。4周为1个疗程,两组患者均治疗3个疗程。观察两组患者观察两组患者治疗前后空腹血糖(FBG),空腹血浆葡萄糖(FPG),餐后2 h血糖(2h PG),糖化血红蛋白(Hb A1c),空腹胰岛素(FINS),糖负荷2 h胰岛素(2hin S),胰岛素抵抗指数(HOMA-IR),胰岛素β细胞功能(HOMA-β),体质量指数(BMI),总胆固醇(TC),甘油三酯(TG),肝脏脂肪含量,临床疗效及治疗后转归情况,并记录不良反应的发生情况。结果:治疗前两组患者各项指标无明显差异。治疗后,对照组以及观察组各项指标均优于治疗前,且观察组指标改变程度均优于对照组,差异均有统计学意义(P<0.05)。观察组总有效率为100.00%,高于对照组的90.00%,差异有统计学意义(P<0.05)。治疗后,对照组出现3例2型糖尿病,2例正常糖耐量,观察组无2型糖尿病出现,出现6例转为正常糖耐量,改善情况显著优于对照组,差异均具有统计学意义(P<0.05)。两组患者不良反应发生率不具有统计学意义(P>0.05)。结论:天麦消渴片可治疗糖耐量异常患者胰岛素抵抗,改善胰岛素β细胞功能,显著降低患者各项生化指标,降低肝脏脂肪含量,有助患者减少2型糖尿病的发生率,且不良反应较少,安全性好,值得临床推广。
Objective ： To investigate the effect of Tianmai Xiaoke Tablet and Metformin Hydrochloride Tablets on insu- lin resistance on islet β cells and liver fat content of patients with impaired glucose tolerance. Methods： During March 2012-June 2015 in our hospital, a total of 120 patients were randomly divided into control group and observation group, 60 cases in each. Two groups were given lifestyle intervention and diet controland treated the treatment - related underly- ing diseases such as blood pressure, lipid and the like. All patients orally took Metformin Hydrochloride Tablets with meals,each 0.5 g,3 times a day. Observation group added Tianmai Xiaoke Tablet,2 tablets,2 times a day. 4 weeks was for a course of treatment and the patients were treated for 3 courses. Before and after treatment, we observed fasting blood glucose （ FBG ）, fasting plasma glucose （ FPG ）, 2 - hour postprandial blood glucose （ 2hPG ）, glycated hemoglobin （ HbA1 c ）, fasting insulin （FINS） ,2 h glucose load insulin （ 2hinS ）, insulin resistance index （ HOMA - IR）, insulin - cell function （ HOMA - 13）, body mass index （ BMI）, total cholesterol （TC）, triglyceride （ TG）, liver fat content, clini- cal efficacy and treatment outcomeand record the occurrence of adverse reactions. Results： The two groups before the treatment showed no significant difference. After treatment,the control group and the observation group＇ s indicators were better than those before treatmentand the degree of change in the observation group was superior to that of the control group. The differences were statistically significant （ P 〈 0. 05 ）. The observation group ＇ s total effective rate was 100. 00% , higher than 90.00% of the control group. The difference was statistically significant （P 〈 0. 05 ）. After treat-ment, the control group had three cases of type 2 diabetes, two cases with normal glucose tolerance. The observation group had no type 2 diabetes and six cases＇ glucose tolerance turned
出处
《中华中医药学刊》
CAS
北大核心
2016年第11期2700-2702,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生一般研究计划项目(2014KYA016)
关键词
糖耐量异常
2型糖尿病
胰岛素抵抗
天麦消渴片
临床疗效
abnormal glucose tolerance, type 2 diabetes
insulin resistance
Tianmai Xiaoke Tablet
clinical curativeeffect
