摘要
目的分析脑血栓形成患者的血脂水平与颈动脉中膜增厚及粥样斑块的临床意义。方法回顾性选取97例首次急性脑血栓形成患者为观察组,选取同期住院的103例神经内科患者为对照组,对两组患者进行血生化检测和颈动脉超声检查,包括血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、脂蛋白a（LPa）、血尿酸（UA）以及颈动脉IMT与粥样斑块的检查,并对检测结果进行统计分析。结果观察组与对照组对比结果显示,两组的TG、UA水平差异无统计学意义;观察组HDL-C水平明显低于对照组,差异有统计学意义（t=-2.970,P=0.003）,TC、LDL-C、LPa水平明显高于对照组,差异有统计学意义（t=5.85,t=4.196,t=3.945;P〈0.05）。观察组左颈动脉IMT为（1.17±0.27）mm、右颈动脉IMT为（1.15±0.30）mm,对照组左IMT为（0.76±0.21）mm,右侧为（0.75±0.22）mm,两组间差异有统计学意义（t=10.339,t=9.493,P〈0.05）;观察组斑块检出率为55.67%、对照组为12.62%,差异有统计学意义（χ2=11.35,χ2=22.42,χ2=41.56,P〈0.05）;斑块性质比较,观察组软斑块检出率为46.30%,对照组为7.69%,差异有统计学意义（χ2=6.575,P〈0.05）。结论血清TC、LDL-C、LPa的水平升高,HDL-C的水平降低,颈动脉IMT增大及粥样斑块形成与脑血栓形成的发生存在相关性。
Objective To analyze the clinical significance of blood lipid level and carotid intima-media thickening and atheromatous plaque in patients with cerebral thrombosis. Methods 97 patients with initial acute cerebral thrombosis formation were retrospectively selected as the observation group and 103 neurological patients hospitalized during the same period were enrolled as the control group. The two groups were performed detection of blood lipid levels and carotid artery intima- media thickness（ IMT） and atheromatous plaque examinations,including serum total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL- C）,lipoprotein a（ LPA）,blood uric acid（ UA） and IMT and plaque.Then the detection results were analyzed. Results The comparative result shows the difference of UA and TG level between the two groups was not statistically significant. The level of HDL- C in the observation group was significantly lower than that in the control group（ t =-2.970,P = 0.003）. The level of TC,LDL-C,LPA in the observation group significantly higher than that in the control group（ t = 5.85,t = 4. 196,t = 3. 945; P〈0. 05）. The left common carotid artery IMT was 1. 17 ± 0. 27 mm and the right carotid artery IMT was 1. 15 ± 0. 30 mm in the observation group,while in the control group,the left IMT was 0. 76 ± 0. 21 mm,and the right side was 0. 75 ±0.22 mm. The differences between the two groups were statistically significant（ t = 10. 339,t = 9. 493,P〈0. 05）.The relevance ratio of plaque was 55. 67% in the observation group and 12. 62% in the control group. The difference was statistically significant（ χ2= 11. 35,χ2= 22. 42,χ2= 41. 56,P〈0. 05）. The relevance ratio of soft plaque was 46. 30% in the observation group and 7. 69% in the control group. The difference was statistically significant（ χ2= 6.575,P〈0. 05）. Conclusions The increase of TC,LDL- C and LPa levels,the decrease of HDL-C level,the increase of c
出处
《齐齐哈尔医学院学报》
2016年第23期2876-2878,共3页
Journal of Qiqihar Medical University
基金
安徽省教育厅质量工程项目(2013sxzx051)
安徽省教育厅教学研究项目(2014jyxm684)
安徽人口职业学院2013年教研课题(jy2013002)共同资助
关键词
脑血栓形成
血脂水平
颈动脉中膜厚度
斑块
相关性
Cerebral thrombosis
Blood lipid level
Carotid intima-media thickness
Plaque
Associated
