摘要
目的探讨5-氨基酮戊酸光动力疗法(5-Aminolevulinic acid mediated photodynamic therapy,ALA-PDT)联合重组人干扰素α2b软膏治疗老年表浅基底细胞癌(Basal cell carcinoma,BCC)患者的疗效。方法选取143例BCC老年患者,随机分为PDT组(72例)和手术组(71例),PDT组采用ALAPDT疗法联合干扰素治疗,手术组采取常规外科手术治疗,对两组患者的疗效、手术创伤面积、病变面积、复发情况、安全性等进行随访比较。结果 PDT组治疗后完全缓解率显著高于手术组(81.94%vs.57.75%,P<0.05),而两组总有效率比较无统计学差异(91.66%vs.81.73%,P>0.05);随访1年后,PDT组患者复发率显著低于手术组(9.72%vs.22.54%,P<0.05);此外,PDT组平均创伤面积、治疗后病变面积也显著小于手术组(P<0.05)。结论 ALA-PDT联合干扰素是一种临床疗效好,复发率低,创伤性小的治疗表浅基底细胞癌的有效方法。
Objective To evaluate the therapeutic effect of 5-aminolevulinic acid mediated photody-namic therapy(ALA-PDT)in combination with recombinant human interferon alpha 2b ointment on superficial basal cell carcinoma(BCC)in elderly.Methods A total of 143 elderly patients with superficial BCC was ran-domly divided into PDT group(n=72 cases)and the surgical group(n=71 cases).The patients in the two groups were given the ALA-PDT in combination with IFN-α2b and routine surgical treatment respectively .The effica-cy after treatment was observed according to surgical wound area , lesion area , recurrence and security during 1 year follow-up.Results The results displayed the complete remission rate of lesion in the PDT group was sig-nificantly higher than that in the surgical group (81.94%vs.57.75%,P〈0.05)after treatment,and the total ef-fective rate of BCC was also higher than that in the surgical group ,but no significant difference was identified in the two groups(91.66%vs.81.73%,P〉0.05).During 1 year follow-up after treatment,the results showed the rate of recurrence in the PDT group was significantly lower than that in the surgical group (9.72% vs.22. 54%,P〈0.05).Moreover,the mean wound area,the lesion area in the PDT group after treatment were also sig-nificantly smaller than that in the surgical group (P〈0.05).Conclusion ALA-PDT in combination with IFN is an effective method with lower recurrence and minor trauma in the treatment of superficial basal cell carcino -ma.
出处
《实用肿瘤学杂志》
CAS
2016年第5期396-399,共4页
Practical Oncology Journal
基金
黑龙江省博士后科研启动基金(LBH-Q15103)
关键词
5-氨基酮戊酸
光动力疗法
干扰素
表浅基底细胞癌
5-Aminolevulinic acid
Photodynamic therapy
Interferon
Superficial basal cell carcinoma