摘要
目的分析中国大陆地区丙型肝炎病毒(HCV)基因型分布特征。方法检索维普数据库、中国知网数据库、万方数据库和PubMed数据库中有关HCV基因型的原始研究文献,按照纳入排除标准剔除不合要求的文献,采用Stata软件进行构成比Meta分析。结果共纳入符合要求的文献40篇,对HCV各亚型进行构成比Meta分析,发现P<0.1,说明不能进行合并分析。不同地区的相同类型患者HCV基因型的分布特征存在明显差异。相同地区的不同类型患者HCV基因型分布特征也存在也明显差异。中国大陆地区HCV亚型仍以1b亚型为主,但6a亚型已超过2a亚型,成为第二大亚型;3b和3a亚型构成比呈增加趋势,其他亚型也在明显增多。结论中国大陆地区HCV亚型呈多样化发展,制定HCV感染防控措施应考虑时间及地域因素。
Objective To study the distribution characteristics of hepatitis C virus（HCV）genotypes in mainland area of China.Methods Original studies about HCV genotypes were retrieved in VIP,CNKI,WanFang Data and PubMed database.Unqualified objects were removed,according to the exclusion standard.Stata software was used to make Meta-analysis of the composition percentage.Results A total of 40 literatures were enrolled.Meta-analysis of composition percentage on the genotypes was with P value less than 0.1,indicating that combined analysis was infeasible.Between different geographical areas,distribution characteristics of HCV genotypes of similar type of patient were obviously distinctive.HCV genotypes distribution of patients of various types from the same geographical area was also obviously distinctive.The dominant HCV subtype in mainland area of China was 1b,yet 6ahas surpassed 2aand became the second popular subtype.The percentages of 3band 3awere increased,and the percentages of other subtypes were also increased obviously.Conclusion Distribution of HCV subtypes in mainland area of China could be with a diversified tendency,thus the time and geographical factors should be considered to adopt prevention policies.
出处
《检验医学与临床》
CAS
2016年第20期2876-2881,共6页
Laboratory Medicine and Clinic
基金
四川省宜宾市科技局医学科研项目(2015SF027)
