摘要
目的观察补肾固冲方联合注射用低分子量肝素钠治疗不明原因复发性流产(URSA)的临床疗效及安全性。方法将63例URSA患者随机分为2组。对照组32例予传统黄体支持保胎方法治疗,治疗组31例在对照组治疗基础上予补肾固冲方联合注射用低分子量肝素钠治疗。比较2组治疗前后血人绒毛膜促性腺激素(HCG)、孕酮(P)及雌二醇(E_2)与孕周相符例数,观察2组治疗前后血小板计数(PLT)、凝血功能及血液流变学指标变化,2组随访早产、足月胎儿成活率。结果治疗组治疗前后HCG、P及E_2与孕周相符例数比较差异有统计学意义(P<0.05)。治疗组治疗前后PLT、凝血功能及血液流变学指标比较差异均有统计学意义(P<0.05),治疗后指标较治疗前改善。治疗组治疗后PLT、APTT、FIB、血浆黏度、全血黏度(高)切及全血黏度(低)切均较对照组治疗后改善(P<0.05)。2组足月胎儿成活率比较差异有统计学意义(P<0.05),治疗组高于对照组。结论补肾固冲方联合注射用低分子量肝素钠治疗URSA,能提高妊娠成功率,安全有效。
Objective To the clinical effects and safety of Bushen- guchong formula combined with low molecular weight heparin sodium injection on unexplained recurrent spontaneous abortion（ URSA）. Methods 63 patients with URSA were randomly divided into two groups. 32 cases in control group were treated by luteal support therapy,31 cases in treatment group were treated by Bushen- guchong formula combined with low molecular weight heparin sodium injection on the basis of control group treatment. The number of human chorionic gonadotropin（ HCG）,progesterone（ P） and estradiol（ E_2） accord with gestational weeks before and after treatment were compared in two groups. The platelet,coagulation function and hemorheology parameters before and after treatment were observed in two groups. The survival rates of premature infant and full- term fetus were follow- up. Results There were statistical differences on the number of HCG,P and E_2 accord with gestational weeks between before and after treatment in treatment group（ P〈0. 05）. There were statistical differences on the platelet,coagulation function and hemorheology parameters between before and after treatment in treatment group（ P〈0. 05）,the parameters were improved after treatment. The survival rate of full- term fetus in treatment group was higher than that in control group,with statistical difference（ P〈0. 05）. Conclusion Bushen- guchong formula combined with molecular weight heparin sodium injection can increased successful pregnancy rates in URSA patients,safe and effective.
出处
《河北中医》
2016年第8期1158-1161,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
流产
习惯性
病因学
中西医结合疗法
Abortion
Habituation
Etiology
Combined therapy of Chinese and western medicine
