摘要
目的探讨贵州省发热出疹性疾病（RFI）病原谱的构成,为制定麻疹消除策略提供依据。方法收集2013-2014年贵州省4个项目县1 044例RFI病例血清标本,采用酶联免疫吸附试验（ELISA）或间接免疫荧光法检测麻疹、风疹、EB病毒、水痘、人类小DNA病毒B19、人疱疹病毒6型Ig M抗体。结果在4个县1 044例RFI监测病例中,手足口、风疹和水痘分别占49.81%,15.61%和8.81%。1 044份血清标本中304份Ig M抗体阳性,阳性率为21.19%;其中风疹、水痘和EB病毒Ig M抗体阳性数分别占总阳性数的43.75%、22.37%和10.20%。一种病原的抗体可以在多种RFI中检出,一种RFI中可以检测出多种病原的抗体。结论小儿各种RFI的临床诊断易误诊,需进一步加强RFI的临床诊断和综合管理,以利于麻疹防控。
Objective To determine the pathogen spectrum of rash and fever illness（ RFI） in Guizhou province,in order to provide evidence for measles elimination strategy development. Methods Serum samples were collected from 1 044 RFI patients reported in 4 project counties of Guizhou from 2013 to2014. Enzyme linked immunosorbent assay（ ELISA） and indirect immunofluorescence were used to detect Ig M antibody to measles virus（ MV）,rubella virus（ RV）,varicella-zoster virus（ VZV）,parvovirus B19（ B19）,Epstein-Barr virus（ EBV）,and human herpesvirus 6（ HHV-6）. Results Among 1 044 reported RFI cases,hand-foot-mouth disease,rubella,and chickenpox accounted for 49. 81%,15. 61 and 8. 81%,respectively; 304 of 1044 serum samples were positive for Ig M antibody,yielding a positive rate of 21. 19%. Among positive samples,RV,VZV,and EBV accounted for 43. 75%,22. 37% and10. 20%,respectively. Ig M antibody for one pathogen was positive in one or more RFI diagnoses,and Ig M antibody of one or more pathogen was positive in one RFI diagnosis. Conclusions RFIs were misdiagnosed frequently. We should strengthen the diagnosis and management of RFIs for measles prevention and control.
出处
《中国疫苗和免疫》
北大核心
2016年第5期502-505,共4页
Chinese Journal of Vaccines and Immunization
基金
贵州省科学技术基金(黔科合J字[2014]2106号)
贵州省传染病预防与控制人才基地资金资助(RC3D1402)
关键词
发热出疹性疾病
血清学监测
Rash and Fever Illness
Serological Surveillance
