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代谢性骨病患者BMD与TRAP、D-Pyr/Cr、NTX/Cr、HOP/Cr的检测及相关性研究 被引量:4

Detection and Correlation Study of BMD and TRAP,D-Pyr/Cr,NTX/Cr,HOP/Cr in Metabolic Bone Disease Patients
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摘要 目的检测代谢性骨病患者跟骨骨密度(bone mineral density,BMD)与四种骨吸收标志物抗酒石酸酸性磷酸酶(tartrate-resistant acid phosphatasey,TRAP)、脱氧吡啶酚(deoxy pyridinoline,D-Pyr)、Ⅰ型胶原N端肽(N-telope tide of typeⅠcollagen,NTX)、尿羟脯氨酸(hydroxyproline,HOP)水平,探讨其相关性。方法采用定量超声法、酶联免疫法、氯氨T化学法测定82例代谢性骨病患者跟骨BMD T值、Z值以及血清TRAP、尿D-Pyr/Cr、尿NTX/Cr、尿HOP/Cr水平,多元回归分析其相关性,并以85例健康人群作对照组。结果代谢性骨病患者跟骨BMD T值、Z值、骨硬度指数下降(P<0.05),男女性T值与年龄负相关,与体质量正相关(P<0.05),而与身高、BMI相关关系不大;患病组血清TRAP、尿D-Pyr/Cr、尿NTX/Cr、尿HOP/Cr水平升高(P<0.05),男性BMD除Z值与TRAP外,T值、Z值均与TRAP、D-Pyr/Cr、NTX/Cr、HOP/Cr负相关(P<0.05),女性T值、Z值与D-Pyr/Cr、NTX/Cr负相关(P<0.05)。结论代谢性骨病患者跟骨BMD下降,骨吸收标志物TRAP、D-PYR、NTX、HOP水平升高,两者存在一定相关性,联合检测可较准确评估患者的骨量变化及病情程度。 Objective To investigate the level of calcaneal bone mineral density( BMD) and four kinds of bone resorption markers as tartrate resistant acid phosphatase( TRAP),deoxypyridinoline( D-Pyr),type I collagen N-terminal peptide( NTX),and urinary hydroxyproline( HOP) in metabolic bone disease patients and to discuss their relevance. Methods The quantitative ultrasound method,enzyme linked immunosorbent assay( ELISA) and ammonia chloride T chemical method were used to determine T value and Z value of the calcaneal BMD,and TRAP in serum,D-Pyr / Cr,NTX / Cr,HOP / Cr in urine of 82 cases with metabolic bone disease,and to analyze the multiple regression correlation to 85 cases of healthy people of control groupResults The BMD T value,Z value,bone stiffness index of patients with metabolic bone disease decreased( P〈0. 05),and the T value was negatively correlated to age,while positive correlation to body mass( P〈0. 05),little correlation to height,BMI;the serum levels of trap,urine D-Pyr / Cr,urine NTX / Cr,urine HOP / Cr level of disease group increased( P〈0. 05); and BMD in male except Z value to TRAP,T value,Z value to TRAP,D-Pyr / Cr,NTX / Cr,and HOP / Cr were in negative correlation( P〈0. 05),and to female T value,Z value to D-Pyr / Cr and NTX / Cr were negative correlation( P〈0. 05). Conclusion The calcaneal BMD of metabolic bone disease patients decreased,the levels of bone resorption markers as TRAP,D-Pyr,NTX,HOP elevated. Both are correlated and union detection can be used for accurate assessment of the changes of bone mineral density and the severity of disease.
作者 吕俊杰 钟彩琴 马长德 丁吉善 Lyu Junjie Zhong Caiqin Ma Changde et al(Department of Oneology, Central Hospital of Jinzhou, Jinzhou 121001, China Department of Neurology, Central Hospital of Jinzhou, Jinzhou 121001, China Medical Experimental Center, Nanyang Institute of Technology, Nanyang 473004, China)
出处 《实用骨科杂志》 2016年第10期902-905,共4页 Journal of Practical Orthopaedics
基金 科技部科技基础性工作专项(2015FY111700)
关键词 代谢性骨病 骨密度 脱氧吡啶酚 I型胶原N端肽 抗酒石酸酸性磷酸酶 尿羟脯氨酸 metabolic bone disease bone mineral density deoxypyridinoline collagen type Ⅰ N-terminal peptide tartrate resistant acid phosphatase urinary hydroxyproline
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