摘要
目的：研究肝细胞肝癌（HCC）、肝转移瘤（HM）和肝血管瘤（HH）患者的肝动脉灌注指数（HPI）以及血管渗透性参数,探讨三维全肝MRI动态增强扫描定量分析在鉴别诊断肝脏肿瘤中的价值。方法：选取58例受检者（HCC组30例,HM组16例,HH组12例）,采用三维容积内插体部检查（VIBE）序列进行全肝磁共振动态增强扫描（DCE-MRI）,并用Omni-Kinetics软件分析图像,结合肝脏双输入血流动力学模型获得肝脏灌注和血管渗透性参数HPI、容积转运常数（Ktrans）、回流速率常数（kep）、血管外细胞外间隙体积比（ve）值和血浆空间容积率（vp）。结果：3组HPI值、Ktrans和kep值差异均有统计学意义（P〈0.05~P〈0.01）;HPI值HCC组〉HH组〉HM组（P〈0.05）;Ktrans值HCC组〉HH组〉HM组（P〈0.05~P〈0.01）;kep值HCC组〉HH组和HM组（P〈0.01）,但HH组和HM组的kep值差异无统计学意义（P〉0.05）;3组ve和vp值差异均无统计学意义（P〉0.05）。结论：三维全肝DCE-MRI扫描可获得定量血流灌注及血管渗透性参数,有助于肝脏肿瘤的鉴别诊断。
Objective：To investigate the hepatic perfusion index（HPI） and vascular permeability parameters in patients with different hepatic tumors, which included hepatoeellular carcinoma （ HCC ）, hepatic metastasis （ HM ） and hepatic haemangiomas （ HH ）, and discuss the clinical diagnosis value of DCE-MRI. Methods：Fifty-eight patients with hepatic tumors （30 cases of HCC, 16 cases of HM and 12 cases HH） were detected by the 3D whole-liver dynamic contrast enhance MRI（DCE-MRI） using volumetric interpolated body examination （VIBE） sequence. The perfusion and vascular permeability parameters （including HPI, Ktrans, kep, ve and vp ） were measured by the Omni-Kinetics software combined with liver model of dual input hemodynamics. Results：There was statistical difference in the values of HPI,Ktrans and kep between three groups（P 〈0.05 to P 〈0. 01 ）. The HPI value in HCC group was significantly higher than that in HH group, and the HPI value was the lowest in HM group （ P 〈 0.05 ）. The Ktrans value in HH group was significantly lower than that in HCC group,and the value was the lowest in HM group（P 〈0.05 to P 〈0.01 ）. The kep value in HCC group was higher than that in HH and HM groups （P 〈 0.01 ） , but there was no statistical difference between HH and HM groups （ P 〉 0.05 ）. The differences of the vp and ve values between three groups were not statistically significant （ P 〉 0.05 ）. Conclusions ： Three-dimensional whole-liver DCE-MRI with the bolus injection of gadodiamide can be used to quantify the perfusion and permeability parameters of hepatic tumors, which is benefit to the differentiation diagnosis of hepatic tumors.
作者
徐运军
程慧敏
翟羽佳
陆杨
XU Yun-jun CHENG Hui-min ZHAI Yu-jia LU Yang(Deptartment of Radiology,Anhtti Provincial Hospital, Hefei Anhui 230001 School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei Anhui 230009, China)
出处
《蚌埠医学院学报》
CAS
2016年第9期1230-1234,共5页
Journal of Bengbu Medical College
基金
国家自然科学基金青年科学基金项目(21501039)
安徽省卫生厅临床医学应用技术项目(2008B039)
关键词
肝肿瘤
磁共振成像
肝脏
动态增强
hepatic tumor
magnetic resonance imaging
liver
dynamic contrast enhancement
