摘要
目的研究肥胖儿童血浆载脂蛋白B(Apo B)/载脂蛋白A1(Apo A1)与颈总动脉内膜中层厚度(CCA IMT)的相关性。方法选择在诸暨市人民医院就诊的53例肥胖儿童和59名正常体检儿童,分别检测空腹血糖(FG)、血浆胰岛素(FI)、总胆固醇(TC)和三酰甘油(TG)等生化指标水平;同时采用高分辨B超监测仪测量肥胖儿童CCA IMT。比较两组儿童各项检测指标水平差异,采用多元回归模型分析肥胖组儿童CCA IMT与各项生化检测指标的相关性。结果肥胖组儿童谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿酸(UA)、TG、TC、低密度脂蛋白胆固醇(LDL-C)、Apo B和Apo B/Apo A1水平以及胰岛β细胞功能指数(HOMA-β)和胰岛素抵抗指数(HOMA-IR)均高于对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)和Apo A1水平均低于对照组(P<0.01);直线相关性分析显示,CCA IMT与Apo A1水平呈负相关,与Apo B/Apo A1、ALT和AST水平呈正相关(P<0.05);多元逐步回归分析结果显示,肥胖儿童Apo B/Apo A1与CCA IMT呈正相关(P<0.05)。结论 Apo B/Apo A1是肥胖儿童CCA IMT的独立影响因素,可能是早期动脉粥样硬化的危险因素。
Objective To explore the relationship between Apo B / Apo A1 ratio and the common carotid arterial intima-media thickness（ CCA IMT） among obese children. Methods A total of 53 obese children in the Zhuji People＇s hospital outpatient were enrolled as obese group. Other 59 no- obese healthy children were recruited as control group. Serum fasting gl UAose（ FG）,fasting insulin（ FI）,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL- C）,low density lipoprotein cholesterol（ LDL- C）,lipoprotein A,apolipoprotein A1（ Apo A1）,apolipoprotein B（ Apo B）,alanine aminotransferase（ ALT）,aspartate amino transferase（ AST）,and uric acid（ UA）were measured in the clinical laboratory. Body mass index（ BMI）,waist to hipline（ W / H） ratio,Apo B / Apo A1 ratio,insulin resistance by homeostasis model（ HOMA- IR）,and β cell function by homeostasis model（ HOMA- β） were calculated. The common carotid arterial IMT of obese children was measured by B- mode ultrasound. All factors between two groups were compared by independent t test. The differences between the two groups were compared,and the correlation between CCA IMT and other factors in obesity group was analyzed by stepwise multiple regression model. Results In the obese group,lg（ ALT）,lg（ AST）,lg（ UA）,ln（ 10＊ TG）,TC,LDL- C,Apo B,Apo B / Apo A1,lg（ HOMA- β）,and ln（ 10＊ HOMA- IR） were significantly higher than those in control group（ P〈0. 05,respectively） while HDL- C and Apo A1 in obese group were lower than those in control group（ P 0. 01,respectively）. Bivariate correlation analysis showed that CCA IMT was inversely correlated with Apo A1 and positively correlated with Apo B / Apo A1,lg（ ALT）,and lg（ AST）（ P〈0. 05,respectively）. Analysis using multiple regression method showed that Apo B/Apo A1 was positively correlated with CCA IMT in these obese children（ P〈0. 05）. Conclusion In obese children,Apo B / Apo A1 was the independent
出处
《预防医学》
2016年第11期1110-1113,共4页
CHINA PREVENTIVE MEDICINE JOURNAL
