摘要
胰腺癌是消化系统中死亡率高、诊断率低且预后极差的一种恶性肿瘤。乙醛脱氢酶(aldehyde dehydrogenases,ALDHs)是细胞内一种烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate,NADP+)依赖的酶,主要参与乙醇、维生素A及环磷酰胺等物质的代谢。最近研究发现,ALDHs的表达参与多种细胞信号通路的调控,且与胰腺癌的转移、预后以及耐药等方面密切相关。此外,ALDHs也可作为正常干细胞与肿瘤干细胞(cancer stem cells,CSCs)的通用标志物,在胰腺癌以及胰腺癌CSCs的发生和发展过程中起着重要的作用。本文综述了ALDHs家族不同亚型的表达与胰腺癌及胰腺癌CSCs的相关性及调控机制,并总结了ALDHs相关抗肿瘤药物的作用机制,以期为胰腺癌的治疗以及新型药物的研制提供理论依据。
Pancreatic cancer is a kind of malignant tumor with high mortality rate, low diagnostic rate, and poor prognosis in the digestive system. Aldehyde dehydrogenases（ALDHs） were the intracellular nicotinamide adenine dinucleotide phosphate（NADP＋）-dependent enzymes, which play an important role in the metabolism of ethanol, vitamin A, cyclophosphamide, etc. Recent studies have found that ALDHs are involved in the regulation of many cell signaling pathways, and their expressions are related to the metastasis, prognosis, and drug-resistance of malignancies. In addition, ALDHs as common markers in normal stem cells and cancer stem cells, play an important role in the occurrence and development of pancreatic cancer and pancreatic cancer stem cells. This review discusses the expression and regulatory mechanisms of different subtypes of ALDHs family in pancreatic cancer and pancreatic cancer stem cells, and summarizes the mechanism of action of ALDHs-related anti-tumor drugs, in order to provide theoretical basis for the treatment of pancreatic cancer and the development of novel drugs.
出处
《肿瘤》
CAS
CSCD
北大核心
2016年第10期1176-1182,共7页
Tumor
关键词
胰腺肿瘤
乙醛脱氢酶
肿瘤干细胞
肿瘤治疗方案
Pancreatic neoplasms
Aldehyde dehydrogenase
Neoplastic stem cells
Antineoplastic protocols
