摘要
目的探讨急性脑干梗死常规治疗中加用丁苯酞注射液的临床价值。方法选择2013—2015年常规治疗中加用丁苯酞注射液的急性脑干梗死患者28例为观察组,同期仅作常规治疗的28例为对照组;采用汉密尔顿焦虑量表(HAMA)排除焦虑心理因素对美国国立卫生研究院卒中量表(NIHSS)的影响后,采用NIHSS评分比较两组患者的治疗效果,检测并比较两组患者治疗前后AST、ALT、肌酐、尿素和WBC等血液指标的变化。结果两组患者治疗前后各时点HAMA评分差异均无统计学意义(均P>0.05);治疗第21天,观察组NIHSS评分为(4.92±1.81)分,明显低于本组治疗第7天(7.15±3.73)分和常规治疗组治疗第21天(6.40±2.17)分,差异均有统计学意义(均P<0.05)。观察组有1例患者治疗期间出现转氨酶轻度升高,停药后恢复正常;两组患者AST、ALT、肌酐、尿素和WBC等血液指标治疗前后差异均无统计学意义(均P>0.05)。结论排除焦虑心理因素后,常规治疗联合丁苯酞注射液对急性脑干梗死患者的神经功能恢复具有一定作用,且不良反应少、安全性好。
Objective To assess the clinical value of butylphthalide injection in treatment of brainstem infarction. Methods Twenty eight patients with acute brainstem infarction received butylphthalide injection in addition to conventional treatment （study group） between 2013 and 2015, and other 28 patients received conventional treatment alone （control group） at the same period. The National Institute of Health Stroke Scale （NIHSS） and Hamilton Anxiety Scale （HAMA） were evaluated before and after treatment in two groups. The blood AST, ALT, creatinine, urea and WBC were measured in both groups. Results There were no statistical differences in HAMA scores before and after treatment between two groups （all P〉0.05）. The NIHSS score in study group at d21 after treatment was significantly lower than that at d7 after treatment （4.92 ± 1.81 vs 7.15 ± 3.73, P 〉0.05）, and also lower than that in control group at 21 days after treatment（4.92 ± 1.81 vs 6.40 ± 2.17, P〉0.05）. Mild elevation of aminotransferases was observed in 1 case of study group during the treatment, and returned to normal after stopping infusing the drug. There were no significant differences in the blood tests between the two groups （all P〉0.05）. Conclusion After excluding the psychological factors, butylphthalide injection is of clinical value in recovery of neural function with safety of patients with brainstem infarction.
出处
《浙江医学》
CAS
2016年第18期1504-1506,共3页
Zhejiang Medical Journal
关键词
丁苯酞
常规治疗
脑干梗死
临床价值
Butylphthalide Routine treatment Brain stem infarctions Clinical value
