摘要
目的:观察益智仁挥发油羟丙基-β-环糊精(HP-β-CD)包合物的制备工艺,并对包合物质量进行研究。方法:以油与HP-β-CD比例、包合温度、包合时间为考察指标,以挥发油利用率、包合物得率为评价指标,采用L9(34)正交试验考察益智仁挥发油HP-β-CD包合工艺条件;采用紫外光谱、气相色谱-质谱法对包合物进行鉴定。结果:最优包合工艺为益智仁挥发油与HP-β-CD的体积重量比为1∶8(mL/g),包合时间2.0h,包合温度为35℃;挥发油性质在包合前后没有发生变化。结论:该包合工艺稳定,省时节能,适合益智仁挥发油的包合,为益智仁中药制剂的研发提供新的方法。
Objective： To study the preparation technology and Quality Control of Inclusion compound of Alpiniae oxyphylla vola- tile oil of Hydroxypropyl-β-Cyclodextrin（HP-β-CD）. Methods：The oil-and HP-β-CD, including temperature, time to index, The u- tilization ratio of volatile Oil , and recovery ratio of the inclusion compound were adopted as evaluation index. Orthogonal test was used to study the HP-β-CD inclusion process of volatile oil of Alpiniae oxyphylla. Using UV, gas chromatography-mass spectrome try to identify inclusion compounds. Results：Optimal inclusion process：the percentage of the volatile Oil to HP-β-CD was 1：8 （mL/ g）, the inlusion time was 2.0h,and the temperature was 35℃. Essential oil properties before and after the package has not changed. Conclusion：The inclusion process is stable, saves time and energy, and is suitable for the inclusion of volatile oil of Alpinia, and provides a new method for the research and development of the traditional Chinese medicine preparation.
出处
《亚太传统医药》
2016年第20期20-23,共4页
Asia-Pacific Traditional Medicine
基金
苏州卫生职业技术学院吴门医药研究发展中心课题(wmyy201507)
关键词
益智仁挥发油
羟丙基-Β-环糊精
包合工艺
The inclusion process is stable, saves time and energy, and is suitable for the inclusion of volatile oil of Alpinia, andprovides a new method for the research and development of the traditional Chinese medicine preparation.
