摘要
目的:探讨血清尿酸(UA)、超敏C反应蛋白(hs-CRP)、左心房内径(LAD)与老年永久性房颤的相关性。方法:选取2012年8月至2015年9月于首都医科大学宣武医院综合科住院的老年永久性房颤患者78例作为房颤组,选取同期住院窦性心律且无房颤病史的老年患者72例作为对照组,记录各组一般资料及超声心动图、尿酸、hs-CRP水平等,进行比较及相关性分析。结果:1与对照组相比,房颤组血清UA及hs CRP水平、左心房内径大小明显增高(P<0.05),2以房颤是否发生为因变量,多因素logistic回归分析显示血清尿酸(OR=2.016,P=0.004)、左房内径(OR=4.180,P=0.001)和hs-CRP(OR=2.846,P=0.002)是老年永久性房颤发生的独立危险因素。3房颤组患者血清尿酸与hs-CRP水平呈正相关(r=0.28,P<0.05),尿酸与左心房内径大小呈轻度正相关(r=0.12,P<0.05)。结论:血清尿酸、hs-CRP、左房内径是老年永久性房颤发生的独立危险因素;尿酸参与的炎症反应和结构重构可能参与老年永久性房颤的发生。
Objective： To investigate the correlation between serum uric acid （UA）, high sensitive C reactive protein （hs-CRP）, left atrial diameter （LAD） and permanent atrial fibrillation （AF） in the elderly. Methods： 78 patients with AF were enrolled in Xuanwu Hospi- tal of Capital University of Medical Sciences Department of General Hospital from August 2012 to September 2015. And 72 cases of el- derly patients with no history of atrial fibrillation in Xuanwu Hospital were chosen as control group during the same period. The levels of uric acid （UA）, hs-CRP were detected, left atrial diameter （LAD） the left ventricular end-diastolic diameter （LVEDD）, left ventricular ejection fraction （LVEF） were measured using color Doppler ultrasound. The data were analyzed and compared between two groups. Results： （1） Compared with control group, the serum levels of UA, hs-CRP level, left atrial diameter size was significantly increased （P〈 0.05） in atrial fibrillation （AF） group. （2） Logistic regression analysis showed that serum uric acid （OR=2.016, P=0.004）, left atrial diame- ter （OR=5.180, P=0.001） and hs-CRP （OR=2.846, P=0.002） were the independent risk factors of elderly permanent atrial fibrillation. （3） The level of serum uric acid was positively correlated （r=0.28, P〈0.05） with hs-CRP level, and was mild positively correlated （r=0.12, P〈0.05） with left atrium diameter. Conclusions： The serum UA, hs CRP and left atrial diameter are the independent risk factors of elderly permanent atrial fibrillation; and might participate in the occurrence of atrial fibrillation via the inflammatory reaction and structural re- modeling.
出处
《现代生物医学进展》
CAS
2016年第29期5644-5647,共4页
Progress in Modern Biomedicine
基金
北京市卫计委保健专项课题(13-01)
关键词
心房颤动
尿酸
超敏C反应蛋白
左心房内径
氧化应激
Atrial fibrillation
Serum uric acid
Hypersensitive c-reactive protein
Left atrial diameter
Oxidative stress
