摘要
目的探讨益气舒心丸治疗病毒性心肌炎(viral myocarditis,VMC)的效果及可能机制。方法选取大庆油田总医院收治的56例VMC患者,按照随机数字表法分为试验组和对照组,各28例。对照组采用常规治疗,试验组在对照组的基础上加用益气舒心丸,比较2组患者临床疗效,以及治疗前后循环血miR、心肌酶谱以及免疫功能的变化。结果试验组治疗总有效率为92.86%,对照组为72.57%,2组比较差异显著(P<0.05);治疗前,2组血清miR-1、miR-133、miR-21、CK-MB、cTnI、LDH、CD3^+、CD4^+、CD8^+、NK无明显差异,治疗后2组miR-1、miR-133、CD3^+、CD4^+、CD8^+、NK均高于治疗前(P<0.05),miR-21、CK-MB、cTnI、LDH均低于治疗前(P<0.05);2组比较,差异均显著(P<0.05)。结论益气舒心丸能够提高VMC患者的治疗效果,其机制可能与改善循环血miR及增强细胞免疫功能有关。
Objective To investigate the effect and mechanism of Yiqi Shuxin pills in the treatment with viral myocarditis（ VMC）. Methods 56 cases of VMC in our hospital were randomly divided into the experimental group and the control group,28 cases in each group. The patients in the control group were with routine treatment,and these in the experimental group were treated with Yiqi Shuxin pills based on the control group. The clinical effects between the two groups were compared,and the changes of miR,myocardial enzyme spectrum and immunity were compared before and after treatment. Results The total effective rate was 92. 86% in the experimental group and was 72. 57% in the control group,there was statistical significance between the two groups（ p〈0. 05）; There was no significant difference between the two groups before treatment at miR-1,miR-133,miR-21,CK-MB,cTnI,LDH,CD3~＋,CD4~＋,CD8~＋,NK in serum; The content of miR-1,miR-133,CD3~＋,CD4~＋,CD8~＋,NK after treatment in the two groups were higher than before treatment（ p〈0. 05）,miR-21,CK-MB,cTnI and LDH were lower than before（ p〈0. 05）; The improvement of these indicators in the experimental group was superior to that in the control group（ p〈0. 05）. Conclusion Yiqi Shuxin pills could improve the therapeutic effect of VMC,the mechanism maybe related to improving the circulation of blood miR and enhance cellular immune function.
出处
《中国生化药物杂志》
CAS
2016年第8期91-93,共3页
Chinese Journal of Biochemical Pharmaceutics
