摘要
目的探讨养血清脑颗粒联合奥拉西坦对轻中度血管性认知功能障碍(VCI)患者认知功能的影响。方法选择本院收治的67例轻中度VCI患者作为研究对象,随机分为观察组(n=34)与对照组(n=33)。对照组用养血清脑颗粒治疗,观察组用养血清脑颗粒联合奥拉西坦治疗,均连续治疗3 w,比较两组治疗前后认知功能(用MMSE及VADAS-Cog量表评价)及不良反应发生率。结果两组治疗前MMSE评分、VADAS-Cog各亚项评分无统计学差异(P﹥0.05);治疗3个月与6个月后,两组MMSE评分升高,VADAS-Cog中单词辨认、单词回忆、回忆测验指令、口语能力的评分均降低(P﹤0.05),且观察组的改善幅度显著大于对照组(P﹤0.05)。治疗6个月后,两组找词困难、命名、定向、注意力、意向性练习、结构性练习、理解能力等评分均降低(P﹤0.05),但两组间无统计学差异(P﹥0.05);观察组不良反应发生率为8.82%,对照组为3.03%,无统计学差异(P﹥0.05)。结论养血清脑颗粒联合奥拉西坦治疗轻中度VCI,利于认知功能的提高,安全性高,对患者恢复具有较大积极作用。
Objective To explore the effects of Yangxue Qingnao Granules combined with Oxiracetam on the cognitive function of patients with mild to moderate vascular cognitive impairment （VCI）. Methods A total of 67 patients with mild to moderate VCI admitted to our hospital were selected and randomly divided into an observation group （n = 34） and a control group （n = 33）. The control group was treated with Yangxue Qingnao Granules and the observation group with Yangxue Qingnao Granules combined with Oxiracetam for three weeks. The cognitive function before and after the treatment （evaluated with MMSE and VADAS-Cog Scales） and the incidence of adverse reactions in the two groups were compared. Resul~ The differences in scores of MMSE and sub-items of VADAS-Cog between the two groups before the treatment were not significant （P 〉 0.05）, Three and six months after the treatment, the MMSE scores of the two groups increased. The scores of word recognition, word recall, recall test instructions and oral ability in VADAS-Cog decreased（P 〈 0.05）. The improvement in the observation group was greater than that in the control group （P 〈 0.05）. Six months after the treatment, the scores of difficulty in finding a word, naming, orientation, attention, intentionality training, structural training and comprehensive ability, etc. in the two groups decreased （P 〈 0.05）. However, there was no significant difference between the two groups after the treatment （P 〉 0.05）. The incidence of adverse reactions in the observation group was 8.82% while that in the control group was 3.03%, showing no significant difference （P 〉 0.05）i Conclusions The treatment of mild to moderate VCI with Yangxue Qingnao Granules combined with Oxiracetam is good for the improvement of cognitive function. The safety is high, and there are positive effects on patients＂ recovery.
出处
《西南国防医药》
CAS
2016年第10期1096-1098,共3页
Medical Journal of National Defending Forces in Southwest China
基金
华北油田分公司科技项目(2015-HB-G11-03)
